GSK 690693

Tocris Bioscience | Catalog # 4144

Akt kinase inhibitor. Antitumor
Tocris Bioscience

Key Product Details

Description

Akt kinase inhibitor. Antitumor
View all Akt (Protein Kinase B) Inhibitors »

Product Description

GSK 690693 is an ATP-competitive pan-Akt kinase inhibitor (IC50 values are 2, 13 and 9 nM of Akt1, 2 and 3 respectively). Also exhibits some inhibition for AMPK, PKA and PAK and PKC isoforms (IC50 < 100 nM). Displays antiproliferative and apoptotic effects in tumor cell lines.

Licensing Information

Sold for research purposes only under agreement from GlaxoSmithKline

Product Specifications for GSK 690693

Molecular Weight

425.48

Formula

C21H27N7O3

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-3-piperidinylmethoxy)-1H-imidazo[4,5-c]pyridin-4-yl]-2-methyl-3-butyn-2-ol

CAS Number

937174-76-0

PubChem ID

90488916

InChI Key

WONPMIMNXYCXKK-AWEZNQCLSA-N

SMILES

NC1=NON=C1C(N3CC)=NC2=C3C(CO[C@@H]4CNCCC4)=CN=C2C#CC(C)(C)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 21.27 50

Preparing Stock Solutions for GSK 690693

The following data is based on the product molecular weight 425.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.70 mL 23.50 mL 47.01 mL
2.5 mM 0.94 mL 4.70 mL 9.40 mL
5 mM 0.47 mL 2.35 mL 4.70 mL
25 mM 0.09 mL 0.47 mL 0.94 mL

Calculators

Calculate the mass, volume, or concentration required for a solution.

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Calculate the dilution required to prepare a stock solution.

x
=
x

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 26 publications citing the usage of this product.

Product Documents for GSK 690693

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for GSK 690693

For research use only

Customer Reviews for GSK 690693 (1)

5 out of 5
1 Customer Rating
5 Stars
100%
4 Stars
0%
3 Stars
0%
2 Stars
0%
1 Stars
0%

Have you used GSK 690693?

Submit a review and receive an Amazon gift card!

$25/€18/£15/$25CAN/¥2500 Yen for a review with an image

$10/€7/£6/$10CAN/¥1110 Yen for a review without an image

Submit a review
Amazon Gift Card
Showing  1 - 1 of 1 review Showing All
Filter By:
Clear Filters X
  • Effects on Akt kinase activation in cancer
    Name: MARINA KOUTSIOUMPA
    Species: Human
    Assay Type: In Vitro
    Verified Customer | Posted 10/18/2022
    GSK 690693 inhibitor was used in studies exploring the role of drug-induced activation of Akt kinase in pancreatic cancer cells. Results were consistent.

There are no reviews that match your criteria.

Showing  1 - 1 of 1 review Showing All