GSK 690693

Catalog # Availability Size / Price Qty
4144/10
4144/50
Akt (Protein Kinase B) Inhibitors Small Molecule
1 Image
Description: Akt kinase inhibitor. Antitumor

Chemical Name: 4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-3-piperidinylmethoxy)-1H-imidazo[4,5-c]pyridin-4-yl]-2-methyl-3-butyn-2-ol

Purity: ≥98%

Product Details
Citations (3)
Supplemental Products
Reviews

Biological Activity

ATP-competitive pan-Akt kinase inhibitor (IC50 values are 2, 13 and 9 nM of Akt1, 2 and 3 respectively). Also exhibits some inhibition for AMPK, PKA and PAK and PKC isoforms (IC50 < 100 nM). Displays antiproliferative and apoptotic effects in tumor cell lines.

Technical Data

M.Wt:
425.48
Formula:
C21H27N7O3
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
937174-76-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes only under agreement from GlaxoSmithKline

Product Datasheets

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Citations for GSK 690693

The citations listed below are publications that use Tocris products. Selected citations for GSK 690693 include:

3 Citations: Showing 1 - 3

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