hh GSK 690693 (CAS 937174-76-0): R&D Systems
Catalog Number: 4144
Chemical Name: 4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-3-piperidinylmethoxy)-1H-imidazo[4,5-c]pyridin-4-yl]-2-methyl-3-butyn-2-ol
Biological Activity
ATP-competitive pan-Akt kinase inhibitor (IC50 values are 2, 13 and 9 nM of Akt1, 2 and 3 respectively). Also exhibits some inhibition for AMPK, PKA and PAK and PKC isoforms (IC50 < 100 nM). Displays antiproliferative and apoptotic effects in tumor cell lines.
Technical Data
  • M.Wt:
    425.48
  • Formula:
    C21H27N7O3
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    937174-76-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes only under agreement from GlaxoSmithKline
Background References
  1. Identification of 4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{(3S)-3-piperidinylmethoxyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl]-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase.
    Heerding et al.
    J.Med.Chem., 2008;51:5663
  2. Characterization of an Akt inhibitor with potent pharmacodynamic and antitumor activity.
    Rhodes et al.
    Cancer Res., 2008;68:2366
Citations:

The citations listed below are publications that use Tocris products. Selected citations for GSK 690693 include:

3 Citations: Showing 1 - 3
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  1. Upregulation of Nicotinic Acetylcholine Receptor α4+β2 through a Ligand-Independent PI3Kβ Mechanism That Is Enhanced by TNFα and the Jak2/p38Mapk Pathways.
    Authors: Rogers and Gahring
    J Mol Neurosci 2015;10:e0143319
  2. Orexins protect neuronal cell cultures against hypoxic stress: an involvement of Akt signaling.
    Authors: Soko&#322;owska Et al.
    Stem Cell Reports 2014;52:48
  3. Fibroblast growth factor-23 abolishes 1,25-dihydroxyvitamin D3-enhanced duodenal calcium transport in male mice.
    Authors: Khuituan Et al.
    Am J Physiol Endocrinol Metab 2012;302:E903

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