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GSK'872

Catalog #: 6492 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6492/10
6492/50
GSK'872 | CAS No. 1346546-69-7 | RIP Kinase Inhibitors
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Description: Potent and selective RIP3 kinase inhibitor

Chemical Name: N-5-Benzothiazolyl-6-[(1-methylethyl)sulfonyl]-4-quinolinamine

Purity: ≥98%

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Biological Activity

GSK'872 is a potent and selective receptor activating protein kinase 3 (RIP3) inhibitor (IC50 = 1.3 nM). Exhibits >1000-fold selectivity for RIP3 over a panel of 300 other kinases including RIP1. Inhibits TNF-induced cell death in 3T3-SA cells and TLR3-induced necrosis in fibroblasts in vitro. Blocks necroptosis of primary human neutrophils from whole blood. Also induces apoptosis at higher concentrations (3 - 10 μM).

Technical Data

M.Wt:
383.49
Formula:
C19H17N3O2S2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1346546-69-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Toll-like receptor 3-mediated necrosis via TRIF, RIP3, and MLKL.
    Kaiser et al.
    J.Biol.Chem., 2013;288:31268
  2. RIP3 induces apoptosis independent of pronecrotic kinase activity.
    Mandal et al.
    Mol.Cell, 2014;56:481

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