GSK'872

Catalog # Availability Size / Price Qty
6492/10
6492/50
Cat.No. 6492 - GSK'872 | C19H17N3O2S2 | CAS No. 1346546-69-7
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Description: Potent and selective receptor activating protein kinase 3 (RIP3) inhibitor

Chemical Name: N-5-Benzothiazolyl-6-[(1-methylethyl)sulfonyl]-4-quinolinamine

Product Details
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Biological Activity

Potent and selective receptor activating protein kinase 3 (RIP3) inhibitor (IC50 = 1.3 nM). Exhibits >1000-fold selectivity for RIP3 over a panel of 300 other kinases including RIP1. Inhibits TNF-induced cell death in 3T3-SA cells and TLR3-induced necrosis in fibroblasts in vitro. Blocks necroptosis of primary human neutrophils from whole blood. Also induces apoptosis at higher concentrations (3 - 10 μM).

Technical Data

Formula:
C19H17N3O2S2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Storage:
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
CAS No:
1346546-69-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Background References

  1. Toll-like receptor 3-mediated necrosis via TRIF, RIP3, and MLKL.
    Kaiser et al.
    J.Biol.Chem., 2013;288:31268
  2. RIP3 induces apoptosis independent of pronecrotic kinase activity.
    Mandal et al.
    Mol.Cell, 2014;56:481

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