GSK'872

Tocris Bioscience | Catalog # 6492

Potent and selective RIP3 kinase inhibitor
Tocris Bioscience

Key Product Details

Description

Potent and selective RIP3 kinase inhibitor
View all RIP Kinase Inhibitors »

Product Description

GSK'872 is a potent and selective receptor activating protein kinase 3 (RIP3) inhibitor (IC50 = 1.3 nM). Exhibits >1000-fold selectivity for RIP3 over a panel of 300 other kinases including RIP1. Inhibits TNF-induced cell death in 3T3-SA cells and TLR3-induced necrosis in fibroblasts in vitro. Blocks necroptosis of primary human neutrophils from whole blood. Also induces apoptosis at higher concentrations (3 - 10 μM).

Product Specifications for GSK'872

Molecular Weight

383.49

Formula

C19H17N3O2S2

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N-5-Benzothiazolyl-6-[(1-methylethyl)sulfonyl]-4-quinolinamine

CAS Number

1346546-69-7

PubChem ID

54674134

InChI Key

ZCDBTQNFAPKACC-UHFFFAOYSA-N

SMILES

CC(S(=O)(C1=CC2=C(N=CC=C2NC3=CC=C4SC=NC4=C3)C=C1)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 38.35 100
Ethanol 38.35 100

Preparing Stock Solutions for GSK'872

The following data is based on the product molecular weight 383.49.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.61 mL 13.04 mL 26.08 mL
5 mM 0.52 mL 2.61 mL 5.22 mL
10 mM 0.26 mL 1.30 mL 2.61 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 24 publications citing the usage of this product.

Product Documents for GSK'872

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for GSK'872

For research use only

Customer Reviews for GSK'872 (2)

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  • Effective necroptosis inhibitor
    Name: JING HE
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: HT-29
    Verified Customer | Posted 06/28/2020
    Working concentration using 10 nM for different incubation time in HT-29 cells and the cell death rate was measured.
    GSK'872 6492
  • Inhibition of necroptosis with GSK872
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: macrophage
    Verified Customer | Posted 09/24/2019
    used to inhibit ripk3 kinase activity to block necroptosis

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