Chemical Name: 3-((4-Cyclohexylpiperazin-1-yl)(1-phenethyl-1H-tetrazol-5-yl)methyl)-6-methoxyquinolin-2(1H)-one
Biological ActivityPotent and selective EAAT2 positive allosteric modulator (EC50 = 0.26 nM). Enhances the glutamate translocation rate, with no effect on substrate interaction. Enhances glutamate uptake by cultured astrocytes by approximately 58%. Exhibits no significant effect on DAT, SERT and NET or NMDA receptors. Neuroprotective in an in vitro model of excitotoxicity.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Identification of novel allosteric modulators of glutamate transporter EAAT2.
Kortagere et al.
ACS Chem Neurosci., 2018;9:522
Novel Positive Allosteric Modulators of Glutamate Transport Have Neuroprotective Properties in an in Vitro Excitotoxic Model.
Falcucci et al.
ACS Chem.Neurosci., 2019;10:3437
Citation for GT 949
The citations listed below are publications that use Tocris products. Selected citations for GT 949 include:
1 Citation: Showing 1 - 1
M�ller Glial Cells Participate in Retinal Waves via Glutamate Transporters and AMPA Receptors.
Authors: Zhang Et al.
Cell Rep 2019;27:2871
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