GTP 14564

Catalog # Availability Size / Price Qty
2086/10
GTP 14564 | CAS No. 34823-86-4 | Additional RTK Inhibitors
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Description: Class III receptor tyrosine kinase (RTK) inhibitor

Chemical Name: 3-Phenyl-1H-benzofuro[3,2-c]pyrazole

Purity: ≥99%

Product Details
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Biological Activity

Potent, selective inhibitor of class III receptor tyrosine kinases (IC50 values are 0.3 μM for c-Fms, c-Kit, FLT3 and ITD-FLT3 and 1 μM for PDGFRβ). Displays no activity against ERK1, ERK2, EGFR, MEK1, HER2, Src, Abl, PKC, PKA and Akt (IC50 > 10 μM). Inhibits FL-dependent proliferation in BaF/ITD-FLT3 cells more potently than BaF/wt-FLT3 cells; anti-leukemic.

Technical Data

M.Wt:
234.26
Formula:
C15H10N2O
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
34823-86-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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