GTP 14564

Key Product Details

Product Description

GTP 14564 is a potent, selective inhibitor of class III receptor tyrosine kinases (IC₅₀ values are 0.3 μM for c-Fms, c-Kit, FLT3 and ITD-FLT3 and 1 μM for PDGFRβ). Displays no activity against ERK1, ERK2, EGFR, MEK1, HER2, Src, Abl, PKC, PKA and Akt (IC₅₀ > 10 μM). Inhibits FL-dependent proliferation in BaF/ITD-FLT3 cells more potently than BaF/wt-FLT3 cells; anti-leukemic.

Product Specifications for GTP 14564

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for GTP 14564

The following data is based on the product molecular weight 234.26.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.27 mL	21.34 mL	42.69 mL
5 mM	0.85 mL	4.27 mL	8.54 mL
10 mM	0.43 mL	2.13 mL	4.27 mL
50 mM	0.09 mL	0.43 mL	0.85 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Yao Human leukemias with mutated FLT3 kinase are synergistically sensitive to FLT3 and Hsp90 inhibitors: the key role of the STAT5 signal transduction pathway. Leukemia 2005 PMID: 16034464
• Murata Selective cytotoxic mechanism of GTP-14564, a novel tyrosine kinase inhibitor in leukemia cells expressing a constitutively active Fms-like tyrosine kinase 3 (FLT3). J.Biol.Chem. 2003 PMID: 12815052

Product Documents for GTP 14564