Partial agonist of α
7 nicotinic acetylcholine receptors (nAChRs); also a weak α
2 and 5-HT3
antagonist at micromolar concentrations. Exhibits improved sensory inhibition in DBA/2 mice following both acute and chronic administration. Also shown to improve memory in several animal models; facilitates hippocampal long-term potentiation.
Soluble to 50 mM in DMSO
Store at -20°C
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All Tocris products are intended for laboratory research use only.
Continuous administration of a selective alpha7 nicotinic partial agonist, DMXBA, improves sensory inhibition without causing tachyphylaxis or receptor upregulation in DBA/2 mice.
Stevens et al.
Nicotinic mechanisms in the treatment of psychotic disorders: a focus on the a7 nicotinic receptor.
Olincy et al.
Effects of anabaseine-related analogs on rat brain nicotinic receptor binding and on avoidance behaviors.
Meyer et al.
Drug Dev.Res., 1994;31:127