Catalog Number: 4557
Alternate Names: DMXBA
Chemical Name: 3-[(2,4-Dimethoxyphenyl)methylene]-3,4,5,6-tetrahydro-2,3'-bipyridine dihydrochloride
Biological Activity
Partial agonist of α7 nicotinic acetylcholine receptors (nAChRs); also a weak α4β2 and 5-HT3 antagonist at micromolar concentrations. Exhibits improved sensory inhibition in DBA/2 mice following both acute and chronic administration. Also shown to improve memory in several animal models; facilitates hippocampal long-term potentiation.
Technical Data
  • M.Wt:
    381.3
  • Formula:
    C19H20N2O2.2HCl
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    156223-05-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Continuous administration of a selective alpha7 nicotinic partial agonist, DMXBA, improves sensory inhibition without causing tachyphylaxis or receptor upregulation in DBA/2 mice.
    Stevens et al.
    Brain.Res., 2010;1352:140
  2. Nicotinic mechanisms in the treatment of psychotic disorders: a focus on the a7 nicotinic receptor.
    Olincy et al.
    Handb.Exp.Pharmacol., 2012;213:211
  3. Effects of anabaseine-related analogs on rat brain nicotinic receptor binding and on avoidance behaviors.
    Meyer et al.
    Drug Dev.Res., 1994;31:127

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