Biological ActivityK v 2.1 and K v 2.2 channel blocker (IC 50 values are 1-3 nM). Enhances glucose-stimulated insulin secretion from human islets in vitro, but not from islet cells lacking the K v 2.1 channel. Has no significant effect on plasma insulin, glucagon or blood glucose levels in mice, but increases plasma somatostatin levels.
(Modifications: Disulfide bridge: 4-19,11-24,18-31)
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Gating modifier peptides as probes of pancreatic beta-cell physiology.
The role of voltage-gated potassium channels Kv2.1 and Kv2.2 in the regulation of Ins and somatostatin release from pancreatic islets.
Li et al.
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Our lab has used Guangxitoxin 1E in several BK channel studies over the last few years. Our results have always been reliable and reproducible. We will surely continue using this product.