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Guangxitoxin 1E

Catalog #: 5676 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5676/100U
Guangxitoxin 1E
1 Image
Description: Potent Kv2.1 and Kv2.2 channel blocker

Purity: ≥95%

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Biological Activity

Guangxitoxin 1E is a Kv2.1 and Kv2.2 channel blocker (IC50 values are 1-3 nM). Enhances glucose-stimulated insulin secretion from human islets in vitro, but not from islet cells lacking the Kv2.1 channel. Has no significant effect on plasma insulin, glucagon or blood glucose levels in mice, but increases plasma somatostatin levels.

Technical Data

M.Wt:
3948.61
Formula:
C178H248N44O45S7
Sequence:
EGECGGFWWKCGSGKPACCPKYVCSPKWGLCNFPMP

(Modifications: Disulfide bridges: 4-19, 11-24, 18-31)

Solubility:
Soluble to 1 mg/ml in water
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
1233152-82-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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