2.1 and Kv
2.2 channel blocker (IC50
values are 1-3 nM). Enhances glucose-stimulated insulin secretion from human islets in vitro
, but not from islet cells lacking the Kv
2.1 channel. Has no significant effect on plasma insulin, glucagon or blood glucose levels in mice, but increases plasma somatostatin levels.
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All Tocris products are intended for laboratory research use only.
The role of voltage-gated potassium channels Kv2.1 and Kv2.2 in the regulation of insulin and somatostatin release from pancreatic islets.
Li et al.
Gating modifier peptides as probes of pancreatic beta-cell physiology.