Catalog Number: 1898
Biological Activity
Endogenous peptide activator of intestinal guanylyl cyclase; secreted mainly by the gastrointestinal mucosa. Regulates water and electrolyte transport in intestinal and renal epithelia.
Technical Data
  • M.Wt:
  • Formula:
  • Sequence:

    (Modifications: Cys-15 = C-terminal OH, Disulfide Bridge between 4 - 2, 7 - 5)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Guanylin and related peptides.
    J.Physiol.Pharmacol., 2001;52:351
  2. Guanylin: an endogenous activator of intestinal guanylate cyclase.
    Currie et al.
    Proc.Natl.Acad.Sci.U.S.A., 1992;89:947
  3. Synthesis, solution structure, binding activity, and cGMP activation of human guanylin and its disulfide isomer.
    Nokihara et al.
    Regul.Pept., 1997;70:111
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