Q: Is GULP1 localized to mitochondria?

A: I am showing based on localization data from UniProt that it may associate with the cytoplasmic side of the plasma membrane: http://www.uniprot.org/uniprot/Q9UBP9 Additional localization data may be found here at Human protein atlas: http://www.proteinatlas.org/ENSG00000144366

Recombinant Human GULP1/CED-6 His Protein

Novus Biologicals | Catalog # NBP2-23097

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Product Specifications
Scientific Data
Preparation & Storage
Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Source

E. coli

Tag

His

Applications

SDS-PAGE

View all GULP1/CED-6 Proteins and Enzymes »

Product Specifications

Description

A recombinant protein with a N-Terminal His-tag and corresponding to the amino acids 1-304 of Human GULP1/CED-6

Source: E.coli

Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MGSMNRAFSR KKDKTWMHTP EALSKHFIPY NAKFLGSTEV EQPKGTEVVR DAVRKLKFAR HIKKSEGQKI PKVELQISIY GVKILEPKTK EVQHNCQLHR ISFCADDKTD KRIFTFICKD SESNKHLCYV FDSEKCAEEI TLTIGQAFDL AYRKFLESGG KDVETRKQIA GLQKRIQDLE TENMELKNKV QDLENQLRIT QVSAPPAGSM TPKSPSTDIF DMIPFSPISH QSSMPTRNGT QPPPVPSRST EIKRDLFGAE PFDPFNCGAA DFPPDIQSKL DEMQEGFKMG LTLEGTVFCL DPLDSRC

Purity

>95%, by SDS-PAGE

Predicted Molecular Mass

36.9 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Protein / Peptide Type

Recombinant Protein

Scientific Data Images for Recombinant Human GULP1/CED-6 His Protein

SDS-PAGE: Recombinant Human GULP1/CED-6 His Protein [NBP2-23097]

SDS-Page: Recombinant Human GULP1/CED-6 Protein [NBP2-23097]

Formulation, Preparation, and Storage

NBP2-23097

Formulation	20 mM Tris-HCl buffer (pH 8.0), 0.15 M NaCl, 50% glycerol, 2 mM DTT
Preservative	No Preservative
Concentration	0.5 mg/ml
Shipping	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage	Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: GULP1/CED-6

PTB domain-containing engulfment adapter protein 1, also known as GULP1, is an evolutionarily conserved adaptor protein required for efficient engulfment of apoptotic cells by phagocytes. GULP1 also helps modulate cellular glycosphingolipid and cholesterol transport. It also may play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increased cytoplasmic levels of GULP1 are associated with increases in cellular levels of GTP-bound ARF6. Recombinant human GULP1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Alternate Names

CED6

Gene Symbol

GULP1

Additional GULP1/CED-6 Products

Product Documents for Recombinant Human GULP1/CED-6 His Protein

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Certificate of Analysis

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Product Specific Notices for Recombinant Human GULP1/CED-6 His Protein

This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 1 year from date of receipt.

Related Research Areas

Apoptosis Adaptor Proteins

Citations for Recombinant Human GULP1/CED-6 His Protein

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