GW 2580

Catalog # Availability Size / Price Qty
5673/50
5673/10
Cat.No. 5673 - GW 2580 | C20H22N4O3 | CAS No. 870483-87-7
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Description: Selective cFMS kinase inhibitor; orally bioavailable

Chemical Name: 5-[[3-Methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]-2,4-pyrimidinediamine

Purity: ≥99%

Product Details
Reviews

Biological Activity

Potent and selective cFMS kinase inhibitor (IC50 = 0.06 μM). Exhibits selectivity for cFMS kinase over 186 other kinases. Inhibits CSF-1-induced growth of rat monocytes in vitro. Also inhibits bone resorption in osteoclast cultures, as well as connective tissue and bone destruction in a rat adjuvant arthritis model. Suppresses M-NFS-60 tumor cell growth in mice. Orally bioavailable.

Technical Data

M.Wt:
366.41
Formula:
C20H22N4O3
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
870483-87-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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