GW 280264X

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GW 280264X | CAS No. 866924-39-2 | Synthetic Metalloprotease Inhibitors
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Description: Potent ADAM10 and ADAM17 inhibitor

Chemical Name: Phenylmethyl N-[(5S)-5-[[(2R,3S)-3-(formylhydroxyamino)-2-(2-methylpropyl)-1-oxohexyl]amino]-6-oxo-6-(2-thiazolylamino)hexyl]carbamate

Purity: ≥98%

Product Details
Citations (1)

Biological Activity

GW 280264X is a potent ADAM (A Disintegrin and Metalloproteinase) 17 and ADAM10 inhibitor (IC50 values of 8 nM and 11.5 nM, respectively). It inhibits constitutive and PMA-inducible CX3CL1 shedding and increases adhesive properties in CX3CL1 transfected cells (IC50 = 1 μM in COS-7 and ECV-304 cells). GW 280264X treatment in mice significantly improves functional recovery after spinal cord injury.

Technical Data

Soluble to 100 mM in DMSO
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. ADAM17-deficiency on microglia but not on macrophages promotes phagocytosis and functional recovery after spinal cord injury
    Sommer D, Corstjens I, Sanchez S et al.
    Brain, Behavior, and Immunity

Product Datasheets

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Citation for GW 280264X

The citations listed below are publications that use Tocris products. Selected citations for GW 280264X include:

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