Chemical Name: 1,3-Dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2H-pyrrolo[3,2-b]pyridin-2-one
Biological ActivityGW 441756 is a potent, selective inhibitor of the NGF receptor tyrosine kinase A (TrkA) (IC50 = 2 nM). Displays > 100-fold selectivity over a range of other kinases.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Discovery and in vitro evaluation of potent TrkA kinase inhibitors: oxindole and aza-oxindoles.
Wood et al.
Citations for GW 441756
The citations listed below are publications that use Tocris products. Selected citations for GW 441756 include:
5 Citations: Showing 1 - 5
Granulocyte-macrophage colony-stimulating factor receptor expression in clinical pain disorder tissues and role in neuronal sensitization.
Authors: Donatien Et al.
Pain Rep 2018;3:e676
Correlating chemical sensitivity and basal gene expression reveals mechanism of action.
Authors: Rees Et al.
Neurotrophin signaling via TrkB and TrkC receptors promotes the growth of brain tumor-initiating cells.
Authors: Lawn Et al.
Nat Chem Biol 2015;290:3814
Effect of brain- and tumor-derived connective tissue growth factor on glioma invasion.
Authors: Edwards Et al.
J Natl Cancer Inst 2011;103:1162
Cellular assays for high-throughput screening for modulators of Trk receptor tyrosine kinases.
Authors: Wang Et al.
Curr Chem Genomics 2008;1:27
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