GW 441756

  ( 4 citations )    
Product Datasheet
Catalog Number:2238
Chemical Name:1,3-Dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2H-pyrrolo[3,2-b]pyridin-2-one
Product Details
Citations (4)
Supplemental Products
Reviews
Biological Activity
Potent, selective inhibitor of the NGF receptor tyrosine kinase A (TrkA) (IC50 = 2 nM). Displays > 100-fold selectivity over a range of other kinases.
Technical Data
  • M.Wt:
    275.31
  • Formula:
    C17H13N3O
  • Solubility:
    Soluble to 15 mM in DMSO
  • Purity:
    >99
  • Storage:
    Store at RT
  • CAS No:
    504433-23-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from GlaxoSmithKline.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for GW 441756 include:

4 Citations: Showing 1 - 4
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  1. Correlating chemical sensitivity and basal gene expression reveals mechanism of action.
    Authors: Rees Et al.
    Oncotarget  2016;12:109
  2. Neurotrophin signaling via TrkB and TrkC receptors promotes the growth of brain tumor-initiating cells.
    Authors: Lawn Et al.
    Nat Chem Biol  2015;290:3814
  3. Effect of brain- and tumor-derived connective tissue growth factor on glioma invasion.
    Authors: Edwards Et al.
    J Natl Cancer Inst  2011;103:1162
  4. Cellular assays for high-throughput screening for modulators of Trk receptor tyrosine kinases.
    Authors: Wang Et al.
    Curr Chem Genomics  2008;1:27

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