Catalog Number: 2238
Chemical Name: 1,3-Dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2H-pyrrolo[3,2-b]pyridin-2-one
Biological Activity
Potent, selective inhibitor of the NGF receptor tyrosine kinase A (TrkA) (IC50 = 2 nM). Displays > 100-fold selectivity over a range of other kinases.
Technical Data
  • M.Wt:
    275.31
  • Formula:
    C17H13N3O
  • Solubility:
    Soluble to 15 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    504433-23-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from GlaxoSmithKline.
Background References
  1. Discovery and in vitro evaluation of potent TrkA kinase inhibitors: oxindole and aza-oxindoles.
    Wood et al.
    Bioorg.Med.Chem.Lett., 2004;14:953
Citations:

The citations listed below are publications that use Tocris products. Selected citations for GW 441756 include:

3 Citations: Showing 1 - 3
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  1. Correlating chemical sensitivity and basal gene expression reveals mechanism of action.
    Authors: Rees Et al.
    Oncotarget 2016;12:109
  2. Neurotrophin signaling via TrkB and TrkC receptors promotes the growth of brain tumor-initiating cells.
    Authors: Lawn Et al.
    Nat Chem Biol 2015;290:3814
  3. Effect of brain- and tumor-derived connective tissue growth factor on glioma invasion.
    Authors: Edwards Et al.
    J Natl Cancer Inst 2011;103:1162

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