GW 441756

Key Product Details

Product Description

GW 441756 is a potent, selective inhibitor of the NGF receptor tyrosine kinase A (TrkA) (IC₅₀ = 2 nM). Displays > 100-fold selectivity over a range of other kinases.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline.

Product Specifications for GW 441756

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for GW 441756

The following data is based on the product molecular weight 275.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.15 mM	24.22 mL	121.08 mL	242.15 mL
0.75 mM	4.84 mL	24.22 mL	48.43 mL
1.5 mM	2.42 mL	12.11 mL	24.22 mL
7.5 mM	0.48 mL	2.42 mL	4.84 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 28 publications citing the usage of this product.

• Wood Discovery and in vitro evaluation of potent TrkA kinase inhibitors: oxindole and aza-oxindoles. Bioorg.Med.Chem.Lett. 2004 PMID: 15013000

Product Documents for GW 441756