GW 583340 dihydrochloride

  ( 1 citations )    
Product Datasheet
Catalog Number:2239
Chemical Name:N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[2-[[[2-(methylsulfonyl)ethyl]amino]methyl]-4-thiazolyl]-4-quinazolinamine dihydrochloride
Product Details
Citations (1)
Supplemental Products
Reviews
Biological Activity
Potent dual EGFR/ErbB2 tyrosine kinase inhibitor (IC50 values are 0.01 and 0.014 μM respectively). Selectively inhibits growth of human tumor cells overexpressing EGFR and ErbB2 (IC50 values are 0.11 μM for inhibition of HN5, N87 and BT474 tumor cell lines vs. > 30 μM for inhibition of non-tumor cell line HFF). Inhibits tumor growth in vivo by ~ 80% in a murine xenograft model following oral administration.
Technical Data
  • M.Wt:
    671.03
  • Formula:
    C28H25ClFN5O3S2.2HCl
  • Solubility:
    Soluble to 100 mM in DMSO with gentle warming
  • Purity:
    >97
  • Storage:
    Desiccate at +4°C
  • CAS No:
    1173023-85-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from GlaxoSmithKline.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for GW 583340 dihydrochloride include:

1 Citations: Showing 1 - 1

  1. GW583340 and GW2974, human EGFR and HER-2 inhibitors, reverse ABCG2- and ABCB1-mediated drug resistance.
    Authors: Sodani Et al.
    Biochem Pharmacol  2012;83:1613

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