GW 583340 dihydrochloride

Catalog # Availability Size / Price Qty
2239/10
2239/50
GW 583340 dihydrochloride | CAS No. 1173023-85-2 | EGF Receptor Inhibitors
1 Image
Description: Potent dual EGFR/ErbB2 inhibitor; orally active

Chemical Name: N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[2-[[[2-(methylsulfonyl)ethyl]amino]methyl]-4-thiazolyl]-4-quinazolinamine dihydrochloride

Purity: ≥97%

Product Details
Citations (1)
Supplemental Products
Reviews

Biological Activity

Potent dual EGFR/ErbB2 tyrosine kinase inhibitor (IC50 values are 0.01 and 0.014 μM respectively). Selectively inhibits growth of human tumor cells overexpressing EGFR and ErbB2 (IC50 values are 0.11 μM for inhibition of HN5, N87 and BT474 tumor cell lines vs. > 30 μM for inhibition of non-tumor cell line HFF). Inhibits tumor growth in vivo by ~ 80% in a murine xenograft model following oral administration.

Technical Data

M.Wt:
671.03
Formula:
C28H25ClFN5O3S2.2HCl
Solubility:
Soluble to 100 mM in DMSO with gentle warming
Purity:
≥97%
Storage:
Desiccate at +4°C
CAS No:
1173023-85-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from GlaxoSmithKline.

Product Datasheets

or select another batch:
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Citation for GW 583340 dihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for GW 583340 dihydrochloride include:

1 Citation: Showing 1 - 1

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for GW 583340 dihydrochloride

There are currently no reviews for this product. Be the first to review GW 583340 dihydrochloride and earn rewards!

Have you used GW 583340 dihydrochloride?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.