Catalog Number: 3658
Chemical Name: P-(4-Methoxyphenyl)-P-4-morpholinylphosphinodithioic acid morpholine salt
Biological Activity
Slow-releasing H2S donor. Exhibits vasodilator and antihypertensive activity. Activity causes slow dilation of blood vessels in vitro and in vivo; does not influence vascular smooth muscle cell viability in culture. Water-soluble.
Technical Data
  • M.Wt:
    376.47
  • Formula:
    C11H16NO2PS2.C4H9NO
  • Solubility:
    Soluble to 100 mM in DMSO
  • Storage:
    Store at -20°C
  • CAS No:
    106740-09-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Hydrogen sulfide donor, GYY4137, exhibits anti-atherosclerotic activity in high fat fed apolipoprotein E-/- mice.
    Liu et al.
    Br.J.Pharmacol. [Epub ahead of print], 2013;
  2. Characterization of a novel, water-soluble hydrogen sulfide-releasing molecule (GYY4137).
    Li et al.
    Circulation, 2008;117:2351
  3. The slow-releasing hydrogen sulfide donor, GYY4137, exhibits novel anti-cancer effects in vitro and in vivo.
    Lee et al.
    PLoS One, 2011;6:e21077
  4. The effect of hydrogen sulfide donors on lipopolysaccaride-induced formation of inflammatory mediators in macrophages.
    Whiteman et al.
    Antioxid.Redox.Signal., 2010;12:1147

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