HA14-1

  ( 2 citations )    
Product Datasheet
Catalog Number:1541
Chemical Name:2-Amino-6-bromo-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester
Product Details
Citations (2)
Reviews
Biological Activity
Cell-permeable inhibitor of Bcl-2 protein (IC50 ~ 9 μM); acts by binding to the surface pocket. Disrupts Bax/Bcl-2 interaction and induces apoptosis of tumor cells. Also binds to the antiapoptotic Blc-2 proteins Bcl-XL and Bcl-w.
Technical Data
  • M.Wt:
    409.23
  • Formula:
    C17H17BrN2O5
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Storage:
    Desiccate at -20°C
  • CAS No:
    65673-63-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for HA14-1 include:

2 Citations: Showing 1 - 2
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  1. Coeloglossum viride var. bracteatum extract protects against amyloid toxicity in rat prefrontal cortex neurons.
    Authors: Qin Et al.
    Blood  2010;3:88
  2. Bcl-2 inhibitor HA14-1 and genistein together adeptly down regulated survival factors and activated cysteine proteases for apoptosis in human malignant neuroblastoma SK-N-BE2 and SH-SY5Y cells.
    Authors: Mohan Et al.
    Brain Res  2009;1283:155

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