HBX 41108

Catalog # Availability Size / Price Qty
4285/10
Deubiquitinating Enzyme Inhibitors Small Molecule
1 Image
Description: Selective USP7 inhibitor

Chemical Name: 7-Chloro-9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile

Purity: ≥98%

Product Details
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Biological Activity

Inhibitor of ubiquitin-specific protease (USP) 7 activity (IC50 = 424 nM). Displays uncompetitive inhibition. Also inhibits USP7-mediated p53 deubiquitination (IC50 = 0.8 μM). Stabilizes p53 and inhibits cancer cell growth; induces p53-dependent apoptosis in p53 wild type and null isogenic cancer cell lines.

Technical Data

M.Wt:
266.64
Formula:
C13H3ClN4O
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
924296-39-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research use only under patent license from Hybrigenics S.A.

Product Datasheets

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