Chemical Name: 7-Chloro-9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile
Biological ActivityInhibitor of ubiquitin-specific protease (USP) 7 activity (IC50 = 424 nM). Displays uncompetitive inhibition. Also inhibits USP7-mediated p53 deubiquitination (IC50 = 0.8 μM). Stabilizes p53 and inhibits cancer cell growth; induces p53-dependent apoptosis in p53 wild type and null isogenic cancer cell lines.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells.
CollF, Formstecher E, Jacq X et al.
Mol Cancer Ther
Synthesis and biological evaluation of 9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile analogues as potential inhibitors of deubiquitinating enzymes.
Colombo et al.
Citations for HBX 41108
The citations listed below are publications that use Tocris products. Selected citations for HBX 41108 include:
2 Citations: Showing 1 - 2
USP7 inhibits Wnt/β-catenin signaling through promoting stabilization of Axin.
Authors: Ji Et al.
Nat Commun 2019;10:4184
Targeting HAUSP in both p53 wildtype and p53-mutant tumors.
Authors: Tavana Et al.
Cell Cycle 2018;:1
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HEK293T cells stably expressing the STF-Luc reporter were pretreated with increasing amounts of USP7 inhibitors HBX41108