Helianorphin-19

Tocris Bioscience | Catalog # 7541

Potent and selective G protein-biased κ opioid receptor (KOR) agonist
Tocris Bioscience
Discontinued Product
7541 has been discontinued. View all Kappa Opioid Receptor Agonists products.

Key Product Details

Description

Potent and selective G protein-biased κ opioid receptor (KOR) agonist
View all Kappa Opioid Receptor Agonists »

Product Description

Helianorphin-19 is a high affinity, potent and selective G protein-biased κ-opioid receptor (KOR) agonist (Ki = 25 nM; EC50 = 45 nM). Helianorphin-19 exhibits approximately 200-fold selectivity for KOR over μ and δ-opioid receptors. In vivo Helianorphin-19 shows potent peripheral analgesic efficacy in a mouse model of visceral pain without affecting motor coordination/sedation.

Product Specifications for Helianorphin-19

Molecular Weight

1790.21

Formula

C81H132N26O16S2

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

2883653-86-7

InChI Key

WEJHFJXWIBZZTQ-AHUOXLFJSA-N

SMILES

O=C(N[C@@H](CC1=CC=C(C=C1)O)C(NCC(NCC(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@H]3CCCNC(N)=N)=O)=O)=O)=O)=O)=O)[C@H](CSSC[C@@H](C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCNC(N)=N)C(N4[C@@H](CCC4)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@H]5CCCCN)=O)=O)=O)=O)=O)=O)NC3=O)NC5=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solubility Soluble to 2mg/ml in water

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Background References

References are publications that support the biological activity of the product.

Product Documents for Helianorphin-19

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Helianorphin-19

For research use only

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