Biological ActivityHemopressin (human, mouse) is a bioactive endogenous peptide substrate for endopeptidase 24.15 (ep24.15), neurolysin (ep24.16) and ACE. Ki values are 27.76, 3.43 and 1.87 μM respectively. Potent hypotensive in vivo. Also acts as a selective CB1 receptor inverse agonist. Displays antinociceptive activity in vivo.
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Novel natural peptide substrates for endopeptidase 24.15, neurolysin, and angiotensin-converting enzyme.
Rioli et al.
Hypotensive effects of hemopressin and bradykinin in rabbits, rats and mice. A comparative study.
Blais et al.
Hemopressin is an inverse agonist of CB1 cannabinoid receptors.
Heimann et al.
Citation for Hemopressin (human, mouse)
The citations listed below are publications that use Tocris products. Selected citations for Hemopressin (human, mouse) include:
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Glucose metabolism links astroglial mitochondria to cannabinoid effects.
Authors: Jimenez-Blasco Et al.
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The endocannabinoid system consists of at least two cannabinoid receptors, CB1 and CB2. Our experiments looked into CB1 receptors using Hemopressin and they were cloned.