Hemopressin (human, mouse)
Tocris Bioscience | Catalog # 3791
Selective CB1 inverse agonist
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Key Product Details
Description
Selective CB1 inverse agonist
Product Description
Hemopressin (human, mouse) is a bioactive endogenous peptide substrate for endopeptidase 24.15 (ep24.15), neurolysin (ep24.16) and ACE. Ki values are 27.76, 3.43 and 1.87 μM respectively. Potent hypotensive in vivo. Also acts as a selective CB1 receptor inverse agonist. Displays antinociceptive activity in vivo.
Product Specifications for Hemopressin (human, mouse)
Molecular Weight
1054.26
Formula
C50H79N13O12
Storage
Store at -20°C
CAS Number
1314035-51-2
PubChem ID
90488877
InChI Key
JEXQOFXDPAGOQL-TZFLQVIRSA-N
SMILES
[H]N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CNC=N1)C(O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
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Solubility
| Solubility | Soluble to 1mg/ml in water |
Calculators
Background References
References are publications that support the biological activity of the product.
- Blais Hypotensive effects of hemopressin and bradykinin in rabbits, rats and mice. A comparative study. Peptides 2005 PMID: 16042973
- Heimann Hemopressin is an inverse agonist of CB1 cannabinoid receptors. Proc.Natl.Acad.Sci.USA
- Rioli Novel natural peptide substrates for endopeptidase 24.15, neurolysin, and angiotensin-converting enzyme. J.Biol.Chem. 2003 PMID: 12500972
Product Documents for Hemopressin (human, mouse)
Certificate of Analysis
To download a Certificate of Analysis, please enter a lot or batch number in the search box below.
Product Specific Notices for Hemopressin (human, mouse)
For research use only
Citations for Hemopressin (human, mouse)
Customer Reviews for Hemopressin (human, mouse) (1)
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Species: HumanVerified Customer | Posted 02/19/2019The endocannabinoid system consists of at least two cannabinoid receptors, CB1 and CB2. Our experiments looked into CB1 receptors using Hemopressin and they were cloned.
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