Biological ActivityBioactive endogenous peptide substrate for endopeptidase 24.15 (ep24.15), neurolysin (ep24.16) and ACE. Ki values are 27.76, 3.43 and 1.87 μM respectively. Potent hypotensive in vivo. Also acts as a selective CB1 receptor inverse agonist. Displays antinociceptive activity in vivo.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Novel natural peptide substrates for endopeptidase 24.15, neurolysin, and angiotensin-converting enzyme.
Rioli et al.
Hypotensive effects of hemopressin and bradykinin in rabbits, rats and mice. A comparative study.
Blais et al.
Hemopressin is an inverse agonist of CB1 cannabinoid receptors.
Heimann et al.
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VersaClone cDNA Plasmids
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The endocannabinoid system consists of at least two cannabinoid receptors, CB1 and CB2. Our experiments looked into CB1 receptors using Hemopressin and they were cloned.