Biological ActivityHemopressin (rat) is a bioactive endogenous peptide substrate for endopeptidase 24.15 (ep24.15), neurolysin (ep24.16) and ACE. Ki values are 27.76, 3.43 and 1.87 μM respectively. Potent hypotensive in vivo. Also acts as a selective CB1 receptor inverse agonist. Displays antinociceptive activity and induces hypophagia in vivo.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Novel natural peptide substrates for endopeptidase 24.15, neurolysin, and angiotensin-converting enzyme.
Rioli et al.
Hemopressin is an inverse agonist of CB1 cannabinoid receptors.
Heimann et al.
The peptide hemopressin acts through CB1 cannabinoid receptors to reduce food intake in rats and mice.
Todd et al.
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