Hemopressin (rat)
Tocris Bioscience | Catalog # 1764
Selective CB1 inverse agonist
Discontinued Product
1764 has been discontinued.
View all Cannabinoid R1 / CB1 Inverse Agonists products.
Key Product Details
Description
Selective CB1 inverse agonist
Product Description
Hemopressin (rat) is a bioactive endogenous peptide substrate for endopeptidase 24.15 (ep24.15), neurolysin (ep24.16) and ACE. Ki values are 27.76, 3.43 and 1.87 μM respectively. Potent hypotensive in vivo. Also acts as a selective CB1 receptor inverse agonist. Displays antinociceptive activity and induces hypophagia in vivo.
Product Specifications for Hemopressin (rat)
Molecular Weight
1088.27
Formula
C53H77N13O12
Storage
Desiccate at -20°C
CAS Number
568588-77-2
PubChem ID
44560117
InChI Key
DUTLYPZZJJBEAJ-QISMNGAHSA-N
SMILES
[H]N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CNC=N1)C(O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
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Solubility
| Solubility | Soluble to 2mg/ml in 20% acetonitrile |
Calculators
Background References
References are publications that support the biological activity of the product.
- Rioli Novel natural peptide substrates for endopeptidase 24.15, neurolysin, and angiotensin-converting enzyme. J.Biol.Chem. 2003 PMID: 12500972
- Todd The peptide hemopressin acts through CB1 cannabinoid receptors to reduce food intake in rats and mice. J.Neurosci. 2010 PMID: 20505104
- Heimann Hemopressin is an inverse agonist of CB1 cannabinoid receptors. Proc.Natl.Acad.Sci.U.S.A. 2007 PMID: 18077343
Product Documents for Hemopressin (rat)
Certificate of Analysis
To download a Certificate of Analysis, please enter a lot or batch number in the search box below.
Product Specific Notices for Hemopressin (rat)
For research use only
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