HEMTAC 26

Key Product Details

Product Description

HEMTAC 26 is a potent HSP90-mediated targeting chimera (HEMTAC) that degrades CDK6 and CDK4 (DC₅₀ values are 19 nM and 26 nM; D_max = 92% and 88% in B16F10 cells, 36h treatment). HEMTAC 26 inhibits growth of a range of cancer cell lines including B16F10 and A375 (IC₅₀ values are 112 nM and 126 nM respectively). Induces cell cycle arrest at G₀/G₁ phase in B16F10 cells.

Product Specifications for HEMTAC 26

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for HEMTAC 26

The following data is based on the product molecular weight 953.51.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.05 mL	5.24 mL	10.49 mL
5 mM	0.21 mL	1.05 mL	2.10 mL
10 mM	0.10 mL	0.52 mL	1.05 mL
50 mM	0.02 mL	0.10 mL	0.21 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Li Targeted protein degradation induced by HEMTACs based on HSP90. J.Med.Chem. 2023 PMID: 36574496

Product Documents for HEMTAC 26