Herbimycin A

Tocris Bioscience | Catalog # 1629

Src family kinase inhibitor. Also Hsp90 inhibitor
Tocris Bioscience
Discontinued Product
1629 has been discontinued. View all Src Family Kinase Inhibitors products.

Key Product Details

Description

Src family kinase inhibitor. Also Hsp90 inhibitor
View all Src Family Kinase Inhibitors »

Product Description

Herbimycin A is an ansamycin antibiotic that acts as a Src family kinase inhibitor. Binds to the SH domain and inhibits the activity of p60v-src and p210BCR-ABL. Exhibits antiangiogenic activity in endothelial cells in vitro. Also inhibits Hsp90 and impairs recovery from heat shock.

Product Specifications for Herbimycin A

Molecular Weight

574.67

Formula

C30H42N2O9

Storage

Store at -20°C

Purity

≥95% (HPLC)

Chemical Name

(15R)-17-demethoxy-15-methoxy-11-O-methyl-geldanamycin

CAS Number

70563-58-5

PubChem ID

6436247

InChI Key

MCAHMSDENAOJFZ-GDYSMBPZSA-N

SMILES

O=C1C=C([C@H](OC)[C@@H](C)C[C@H](OC)[C@H](OC)[C@@H](C)/C=C(C)/[C@H](OC(N)=O)[C@@H](OC)/C=C/C=C(C)/C2=O)C(C(N2)=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 1 2

Preparing Stock Solutions for Herbimycin A

The following data is based on the product molecular weight 574.67.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.02 mM 87.01 mL 435.03 mL 870.06 mL
0.1 mM 17.40 mL 87.01 mL 174.01 mL
0.2 mM 8.70 mL 43.50 mL 87.01 mL
1 mM 1.74 mL 8.70 mL 17.40 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 8 publications citing the usage of this product.

Product Documents for Herbimycin A

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Herbimycin A

For research use only

Customer Reviews for Herbimycin A (1)

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  • We studied mechanisms of resistance to Herbimycin A
    Name: Anonymous
    Species: Human
    Verified Customer | Posted 02/27/2019
    We studied mechanisms of resistance to Herbimycin A (ansamycin antibiotics) in human breast cancer cell lines.
    Herbimycin A 1629

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