Chemical Name: (15R)-17-demethoxy-15-methoxy-11-O-methyl-geldanamycin
Biological ActivityHerbimycin A is an ansamycin antibiotic that acts as a Src family kinase inhibitor. Binds to the SH domain and inhibits the activity of p60v-src and p210BCR-ABL. Exhibits antiangiogenic activity in endothelial cells in vitro. Also inhibits Hsp90 and impairs recovery from heat shock.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Labeling of v-Src and BCR-ABL tyrosine kinases with [14C]herbimycin A and its use in the elucidation of the kinase inactivation mechanism.
Fukazawa et al.
FEBS Lett., 1994;340:155
Herbimycin A inhibits angiogenic activity in endothelial cells and reduces neovascularization in a rat model of retinopathy of prematurity.
McCollum et al.
Exp.Eye Res., 2004;78:987
Inhibition of Hsp90 function delays and impairs recovery from heat shock.
FEBS J., 2005;272:5244
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