Hexa-D-arginine

Name: Hexa- D -arginine
Brand: Tocris Bioscience
SKU: 4711

Tocris Bioscience | Catalog # 4711

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Citations (7)

Product Documents

Furin inhibitor

Discontinued Product

4711 has been discontinued. View all Furin Inhibitors products.

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices
Research Areas

Key Product Details

Description

Furin inhibitor

View all Furin Inhibitors »

Product Description

Hexa-D-arginine is an inhibitor of furin (K_i values are 0.106, 0.58 and 13.2 μM for furin, PACE4 and PC1 respectively).

Product Specifications for Hexa-D-arginine

Molecular Weight

954.16

Formula

C₃₆H₇₅N₂₅O₆

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

673202-67-0

PubChem ID

57358476

InChI Key

BMLTZEAFQLJTIZ-TZNXUKFXSA-N

SMILES

[H]N[C@H](CCCNC(N)=N)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H](CCCNC(N)=N)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 2mg/ml in water

Calculators

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

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g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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Concentration 1 (C1)

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Concentration 2 (C2)

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The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 7 publications citing the usage of this product.

Cameron Polyarginines are potent furin inhibitors. J.Biol.Chem. 2000 PMID: 10958789
Cheng Furin inhibitors block SARS-CoV-2 spike protein cleavage to suppress virus production and cytopathic effects. Cell Rep. 2020 PMID: 33007239
Yuan Hexa-D-arginine treatment increases 7B2.PC2 activity in hyp-mouse osteoblasts and rescues the HYP phenotype. J.Bone Miner.Res. 2012 PMID: 22886699

Product Documents for Hexa-D-arginine

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Download SDS

Product Specific Notices for Hexa-D-arginine

For research use only

Related Research Areas

Notch Pathway

Serine Proteases and Regulators

Citations for Hexa-D-arginine

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