Biological ActivityInhibitor of furin (Ki values are 0.106, 0.58 and 13.2 μM for furin, PACE4 and PC1 respectively).
(Modifications: Arg-6 = C-terminal amide, Arg-1,2,3,4,5,6=D-Arg)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Hexa-D-arginine treatment increases 7B2.PC2 activity in hyp-mouse osteoblasts and rescues the HYP phenotype.
Yuan et al.
J.Bone Miner.Res., 2012;28:56
Polyarginines are potent furin inhibitors.
Cameron et al.
Citation for Hexa-D-arginine
The citations listed below are publications that use Tocris products. Selected citations for Hexa-D-arginine include:
1 Citation: Showing 1 - 1
Biowire Model of Interstitial and Focal Cardiac Fibrosis.
Authors: Wang Et al.
ACS Cent Sci 2019;5:1146
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