Biological ActivityInhibitor of furin (Ki values are 0.106, 0.58 and 13.2 μM for furin, PACE4 and PC1 respectively).
(Modifications: Arg-6 = C-terminal amide, Arg-1,2,3,4,5,6=D-Arg)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Hexa-D-arginine treatment increases 7B2.PC2 activity in hyp-mouse osteoblasts and rescues the HYP phenotype.
Yuan et al.
J.Bone Miner.Res., 2012;28:56
Polyarginines are potent furin inhibitors.
Cameron et al.
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