HI TOPK 032
Chemical Name: N-(12-Cyanoindolizino[2,3-b]quinoxalin-2-yl)-2-thiophenecarboxamide
Biological ActivityHI TOPK 032 is a T-LAK-cell-originated protein kinase (TOPK) inhibitor; exhibits selectivity for TOPK over other MAPKK family members including ERK1, JNK1 and p38. Blocks proliferation of HCT116 colon cancer cells; suppresses tumor growth in a colon cancer xenograft model. Also inhibits Chk1 (IC50 = 9.6 μM).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Discovery of novel checkpoint kinase 1 inhibitors by virtual screening based on multiple crystal structures.
Li et al.
Novel TOPK inhibitor HI-TOPK-032 effectively suppresses colon cancer growth.
Kim et al.
Cancer Res., 2012;72:3060
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for HI TOPK 032
There are currently no reviews for this product. Be the first to review HI TOPK 032 and earn rewards!
Have you used HI TOPK 032?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image