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HI TOPK 032

4555 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4555/10
Other MAPK Compounds Small Molecule
1 Image
Description: Selective T-LAK-cell-originated protein kinase (TOPK) inhibitor

Chemical Name: N-(12-Cyanoindolizino[2,3-b]quinoxalin-2-yl)-2-thiophenecarboxamide

Purity: ≥98%

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Biological Activity

T-LAK-cell-originated protein kinase (TOPK) inhibitor; exhibits selectivity for TOPK over other MAPKK family members including ERK1, JNK1 and p38. Blocks proliferation of HCT116 colon cancer cells; suppresses tumor growth in a colon cancer xenograft model. Also inhibits Chk1 (IC50 = 9.6 μM).

Technical Data

M.Wt:
369.4
Formula:
C20H11N5OS
Solubility:
Soluble to 20 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
487020-03-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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