HI TOPK 032

Catalog # Availability Size / Price Qty
4555/10
Cat.No. 4555 - HI TOPK 032 | C20H11N5OS | CAS No. 487020-03-1
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Description: Selective T-LAK-cell-originated protein kinase (TOPK) inhibitor

Chemical Name: N-(12-Cyanoindolizino[2,3-b]quinoxalin-2-yl)-2-thiophenecarboxamide

Purity: ≥98%

Product Details
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Biological Activity

T-LAK-cell-originated protein kinase (TOPK) inhibitor; exhibits selectivity for TOPK over other MAPKK family members including ERK1, JNK1 and p38. Blocks proliferation of HCT116 colon cancer cells; suppresses tumor growth in a colon cancer xenograft model. Also inhibits Chk1 (IC50 = 9.6 μM).

Technical Data

M.Wt:
369.4
Formula:
C20H11N5OS
Solubility:
Soluble to 20 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
487020-03-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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