HI TOPK 032
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Description: Selective T-LAK-cell-originated protein kinase (TOPK) inhibitor
Chemical Name: N-(12-Cyanoindolizino[2,3-b]quinoxalin-2-yl)-2-thiophenecarboxamide
Purity: ≥98%
Biological Activity
T-LAK-cell-originated protein kinase (TOPK) inhibitor; exhibits selectivity for TOPK over other MAPKK family members including ERK1, JNK1 and p38. Blocks proliferation of HCT116 colon cancer cells; suppresses tumor growth in a colon cancer xenograft model. Also inhibits Chk1 (IC50 = 9.6 μM).Technical Data
M.Wt:
369.4
Formula:
C20H11N5OS
Solubility:
Soluble to 20 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
487020-03-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
-
Discovery of novel checkpoint kinase 1 inhibitors by virtual screening based on multiple crystal structures.
Li et al.
J.Chem.Inf.Model., 2011;51:2904 -
Novel TOPK inhibitor HI-TOPK-032 effectively suppresses colon cancer growth.
Kim et al.
Cancer Res., 2012;72:3060
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