HI TOPK 032
Chemical Name: N-(12-Cyanoindolizino[2,3-b]quinoxalin-2-yl)-2-thiophenecarboxamide
Biological ActivityT-LAK-cell-originated protein kinase (TOPK) inhibitor; exhibits selectivity for TOPK over other MAPKK family members including ERK1, JNK1 and p38. Blocks proliferation of HCT116 colon cancer cells; suppresses tumor growth in a colon cancer xenograft model. Also inhibits Chk1 (IC50 = 9.6 μM).
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Discovery of novel checkpoint kinase 1 inhibitors by virtual screening based on multiple crystal structures.
Li et al.
Novel TOPK inhibitor HI-TOPK-032 effectively suppresses colon cancer growth.
Kim et al.
Cancer Res., 2012;72:3060
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