Chemical Name: N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]-2-oxo-3-piperidinecarboxamide
Biological ActivitySelective TrkB receptor agonist. Protects neurons from excitotoxicity. Protects retinas from light-induced retinal degeneration (LIRD) in vivo. Blood brain barrier and blood-retinal barrier penetrant.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Gram-scale, chemoselective synthesis of N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-2-oxopiperidine-3-carboxamide (HIOC)
Setterholm et al.
Tetrahedron Lett., 2015;56:3413
N-acetyl serotonin derivatives as potent neuroprotectants for retinas
Shen et al.
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