Chemical Name: 5,7-Dihydroxy-2-(4-hydroxyphenyl)-6-methoxy-4H-1-benzopyran-4-one
Biological ActivityHispidulin is a partial positive allosteric modulator at the benzodiazepine receptor (IC50 = 1.3 μM for inhibition of flumazenil binding); natural sage flavone. Stimulates GABA-induced chloride currents in Xenopus oocytes expressing α1-, α2-, α3-, α5- or α6-β2 γ2S GABAA receptors. Brain penetrant; oral administration reduces seizures in a gerbil model of epilepsy. Also has antifungal, antiproliferative, antioxidant and antithrombotic properties.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Hispidulin, a natural flavone, inhibits human platelet aggregation by increasing cAMP levels.
Bourdillat et al.
Constituents of sage (Salvia officinalis) with in vitro affinity to human brain benzodiazepine receptor.
Kavvadias et al.
Planta Med., 2003;69:113
The flavone hispidulin, a benzodiazepine receptor ligand with positive allosteric properties, traverses the blood-brain barrier and exhibits anticonvulsive effects.
Kavvadias et al.
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