Hispidulin
Chemical Name: 5,7-Dihydroxy-2-(4-hydroxyphenyl)-6-methoxy-4H-1-benzopyran-4-one
Purity: ≥98%
Biological Activity
Partial positive allosteric modulator at the benzodiazepine receptor (IC50 = 1.3 μM for inhibition of flumazenil binding); natural sage flavone. Stimulates GABA-induced chloride currents in Xenopus oocytes expressing α1-, α2-, α3-, α5- or α6-β2 γ2S GABAA receptors. Brain penetrant; oral administration reduces seizures in a gerbil model of epilepsy. Also has antifungal, antiproliferative, antioxidant and antithrombotic properties.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Hispidulin, a natural flavone, inhibits human platelet aggregation by increasing cAMP levels.
Bourdillat et al.
Eur.J.Pharmacol., 1988;147:1 -
Constituents of sage (Salvia officinalis) with in vitro affinity to human brain benzodiazepine receptor.
Kavvadias et al.
Planta Med., 2003;69:113 -
The flavone hispidulin, a benzodiazepine receptor ligand with positive allosteric properties, traverses the blood-brain barrier and exhibits anticonvulsive effects.
Kavvadias et al.
Br.J.Pharmacol., 2004;142:811
Product Datasheets
Reconstitution Calculator
Molarity Calculator
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for Hispidulin
There are currently no reviews for this product. Be the first to review Hispidulin and earn rewards!
Have you used Hispidulin?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image