Hispidulin

Catalog # Availability Size / Price Qty
2174/10
Hispidulin | CAS No. 1447-88-7 | GABA-A Receptor Benzodiazepines
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Description: Partial positive allosteric modulator at the benzodiazepine site
Alternative Names: Dinatin

Chemical Name: 5,7-Dihydroxy-2-(4-hydroxyphenyl)-6-methoxy-4H-1-benzopyran-4-one

Purity: ≥98%

Product Details
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Biological Activity

Partial positive allosteric modulator at the benzodiazepine receptor (IC50 = 1.3 μM for inhibition of flumazenil binding); natural sage flavone. Stimulates GABA-induced chloride currents in Xenopus oocytes expressing α1-, α2-, α3-, α5- or α6-β2 γ2S GABAA receptors. Brain penetrant; oral administration reduces seizures in a gerbil model of epilepsy. Also has antifungal, antiproliferative, antioxidant and antithrombotic properties.

Technical Data

M.Wt:
300.27
Formula:
C16H12O6
Solubility:
Soluble to 25 mM in DMSO and to 10 mM in ethanol
Purity:
≥98%
Storage:
Desiccate at -20°C
CAS No:
1447-88-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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