E2F transcription factor inhibitor; inhibits E2F DNA binding activity. Inhibits E2F4 DNA binding and reduces E2F4 protein levels in A375 melanoma cells. Induces apoptosis of A375 and MDA-MB-231 breast cancer cells. Inhibits A375 proliferation and invasion in a three dimensional skin model of A375 invasion. Also attenuates human embryonic stem cell proliferation.
Soluble to 20 mM in DMSO
Store at -20°C
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All Tocris products are intended for laboratory research use only.
A small-molecule E2F inhibitor blocks growth in a melanoma culture model.
Ma et al.
Cancer Res., 2008;68:6292
The RB family is required for the self-renewal and survival of human embryonic stem cells.
Conklin et al.