HLM 006474

Key Product Details

Product Description

HLM 006474 is an E2F transcription factor inhibitor; inhibits E2F DNA binding activity. Inhibits E2F4 DNA binding and reduces E2F4 protein levels in A375 melanoma cells. Induces apoptosis of A375 and MDA-MB-231 breast cancer cells. Inhibits A375 proliferation and invasion in a three dimensional skin model of A375 invasion. Also attenuates human embryonic stem cell proliferation.

Product Specifications for HLM 006474

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for HLM 006474

The following data is based on the product molecular weight 399.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	12.52 mL	62.58 mL	125.16 mL
1 mM	2.50 mL	12.52 mL	25.03 mL
2 mM	1.25 mL	6.26 mL	12.52 mL
10 mM	0.25 mL	1.25 mL	2.50 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

• Conklin The RB family is required for the self-renewal and survival of human embryonic stem cells. Nat.Commun. 2012 PMID: 23212373
• Ma A small-molecule E2F inhibitor blocks growth in a melanoma culture model. Cancer Res. 2008 PMID: 18676853

Product Documents for HLM 006474