Chemical Name: 7-[(4-Ethoxy-3-methylphenyl)(2-pyridinylamino)methyl]-2-methyl-8-quinolinol
Biological ActivityHLM 006474 is an E2F transcription factor inhibitor; inhibits E2F DNA binding activity. Inhibits E2F4 DNA binding and reduces E2F4 protein levels in A375 melanoma cells. Induces apoptosis of A375 and MDA-MB-231 breast cancer cells. Inhibits A375 proliferation and invasion in a three dimensional skin model of A375 invasion. Also attenuates human embryonic stem cell proliferation.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Complete Your Research
The RB family is required for the self-renewal and survival of human embryonic stem cells.
Conklin et al.
A small-molecule E2F inhibitor blocks growth in a melanoma culture model.
Ma et al.
Cancer Res., 2008;68:6292
Citation for HLM 006474
The citations listed below are publications that use Tocris products. Selected citations for HLM 006474 include:
1 Citation: Showing 1 - 1
BRD4 regulates cellular senescence in gastric cancer cells via E2F/miR-106b/p21 axis.
Cell Death Dis 2018;9(2):203
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