HLM 006474

  ( 1 citations )    
Product Datasheet
Catalog Number:5283
Chemical Name:7-[(4-Ethoxy-3-methylphenyl)(2-pyridinylamino)methyl]-2-methyl-8-quinolinol
Product Details
Citations (1)
Reviews
Biological Activity
E2F transcription factor inhibitor; inhibits E2F DNA binding activity. Inhibits E2F4 DNA binding and reduces E2F4 protein levels in A375 melanoma cells. Induces apoptosis of A375 and MDA-MB-231 breast cancer cells. Inhibits A375 proliferation and invasion in a three dimensional skin model of A375 invasion. Also attenuates human embryonic stem cell proliferation.
Technical Data
  • M.Wt:
    399.48
  • Formula:
    C25H25N3O2
  • Solubility:
    Soluble to 20 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at -20°C
  • CAS No:
    353519-63-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for HLM 006474 include:

1 Citations: Showing 1 - 1

  1. BRD4 regulates cellular senescence in gastric cancer cells via E2F/miR-106b/p21 axis.
    Authors: Dong
    Cell Death Dis  2018;9(2):203

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