HLM 006474
Chemical Name: 7-[(4-Ethoxy-3-methylphenyl)(2-pyridinylamino)methyl]-2-methyl-8-quinolinol
Purity: ≥98%
Biological Activity
HLM 006474 is an E2F transcription factor inhibitor; inhibits E2F DNA binding activity. Inhibits E2F4 DNA binding and reduces E2F4 protein levels in A375 melanoma cells. Induces apoptosis of A375 and MDA-MB-231 breast cancer cells. Inhibits A375 proliferation and invasion in a three dimensional skin model of A375 invasion. Also attenuates human embryonic stem cell proliferation.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Complete Your Research
Background References
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The RB family is required for the self-renewal and survival of human embryonic stem cells.
Conklin et al.
Nat.Commun., 2012;3:1244 -
A small-molecule E2F inhibitor blocks growth in a melanoma culture model.
Ma et al.
Cancer Res., 2008;68:6292
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Citation for HLM 006474
The citations listed below are publications that use Tocris products. Selected citations for HLM 006474 include:
1 Citation: Showing 1 - 1
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BRD4 regulates cellular senescence in gastric cancer cells via E2F/miR-106b/p21 axis.
Authors: Dong
Cell Death Dis 2018;9(2):203
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