Chemical Name: 3-Hydroxy-1,2,3-benzotriazin-4(3H)-one
Biological ActivityHODHBt is a STAT5-SUMO protein-protein interaction inhibitor. Blocks SUMOylation of phosphorylated STAT5. Reactivates latent HIV-1 reservoir in central memory T cells (TCM). Increases viral release by ~2.7-fold at a concentration of 100 μM in combination with IL-2 compared to unstimulated cells; reduces size of latent HIV-1 reservoir in vitro.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Benzotriazoles reactivate latent HIV-1 through inactivation of STAT5 SUMOylation.
Bosque et al.
Cell Rep., 2017;18:1324
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