Human C1q R1/CD93 APC-conjugated Antibody

    
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  • Species Reactivity
    Human
  • Specificity
    Detects human C1q R1/CD93 in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross‑reactivity with recombinant mouse C1q R1 is observed.
  • Source
    Monoclonal Mouse IgG1 Clone # 273107
  • Purification
    Protein A or G purified from hybridoma culture supernatant
  • Immunogen
    Mouse myeloma cell line NS0-derived recombinant human C1q R1/CD93
    Ala24-Lys580
    Accession # Q9NPY3
  • Formulation
    Supplied in a saline solution containing BSA and Sodium Azide.
  • Label
    Allophycocyanin
Product Datasheets

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Applications
  •  
    Recommended
    Concentration
    Sample
  • Flow Cytometry
    10 µL/106 cells
    See below
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Data Example
Detection of C1q R1/CD93 in Human Blood Monocytes by Flow Cytometry. Human peripheral blood monocytes were stained with Mouse Anti-Human C1q R1/CD93 APC‑conjugated Monoclonal Antibody (Catalog # FAB23791A, filled histogram) or isotype control antibody (Catalog # IC002A, open histogram). View our protocol for Staining Membrane-associated Proteins.
Preparation and Storage
  • Shipping
    The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
  • Stability & Storage
    Protect from light. Do not freeze.
    • 12 months from date of receipt, 2 to 8 °C as supplied.
Background: C1q R1/CD93
C1q R1 is also known as C1q Rp, Collectin Receptor, and AA4 antigen, and is designated CD93. C1q R1 mediates enhanced phagocytosis by monocytes and macrophages upon interaction with soluble defense collagens including C1q, MBL, and SP-A (1, 2). It is a type I transmembrane glycoprotein expressed on endothelial cells, hematopoietic progenitor cells, platelets, and cells of myeloid origin. C1q R1 has also been identified as a stem cell marker (3, 4).
  • References:
    1. Kim, T.S. et al. (2000) Mol. Immunol. 37:377.
    2. Dean, Y.D. et al. (2001) Eur. J. Immunol. 31:1370.
    3. Petrenko, O. et al. (1999) Immunity 10:691.
    4. Danet, G.H. et al. (2002) Proc. Natl. Acad. Sci. USA 99:10441.
  • Long Name:
    Complement Component C1q Receptor
  • Entrez Gene IDs:
    22918 (Human); 17064 (Mouse); 84398 (Rat)
  • Alternate Names:
    AA4 Antigen; C1q R1; C1q receptor 1; C1q Rp; C1q/MBL/SPA receptor; C1qR(P); C1qR1; C1qRp; CD93 antigenC1qR; CD93 molecule; CD93; CDw93C1QR1; Collectin Receptor; Complement component 1 q subcomponent receptor 1; complement component 1, q subcomponent, receptor 1; complement component C1q receptor; dJ737E23.1; ECSM3; Ly68; Matrix-remodeling-associated protein 4; matrix-remodelling associated 4; MXRA4
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Isotype Controls
Description Application Cat# Citations Images  

Mouse IgG1 APC-conjugated Antibody

Ctrl IC002A 11  
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Staining Reagents
Description Application Cat# Citations Images  

Flow Cytometry Staining Buffer (1X)

Flow FC001 7
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Flow Cytometry Mouse Lyse Buffer (10X)

Flow FC003 5
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Flow Cytometry Human Lyse Buffer (10X)

Flow FC002 1
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