Detection of C1q R1/CD93 in Human Blood Monocytes by Flow Cytometry.
Human peripheral blood monocytes were stained with Mouse Anti-Human C1q R1/CD93 APC‑conjugated Monoclonal Antibody (Catalog # FAB23791A, filled histogram) or isotype control antibody (Catalog # IC002A, open histogram). View our protocol for Staining Membrane-associated Proteins.
Preparation and Storage
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze.
12 months from date of receipt, 2 to 8 °C as supplied.
Background: C1q R1/CD93
C1q R1 is also known as C1q Rp, Collectin Receptor, and AA4 antigen, and is designated CD93. C1q R1 mediates enhanced phagocytosis by monocytes and macrophages upon interaction with soluble defense collagens including C1q, MBL, and SP-A (1, 2). It is a type I transmembrane glycoprotein expressed on endothelial cells, hematopoietic progenitor cells, platelets, and cells of myeloid origin. C1q R1 has also been identified as a stem cell marker (3, 4).
Kim, T.S. etal. (2000) Mol. Immunol. 37:377.
Dean, Y.D. et al. (2001) Eur. J. Immunol. 31:1370.
Petrenko, O. et al. (1999) Immunity 10:691.
Danet, G.H. et al. (2002) Proc. Natl. Acad. Sci. USA 99:10441.
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