Human Calcitonin R APC-conjugated Antibody

FAB4614A has been discontinued. View all Calcitonin R products.
  
  • Species Reactivity
    Human
  • Specificity
    Detects human Calcitonin R. Stains human Calcitonin R transfectants but not irrelevant transfectants.
  • Source
    Monoclonal Mouse IgG2A Clone # 462802
  • Purification
    Protein A or G purified from hybridoma culture supernatant
  • Immunogen
    HEK293 human embryonic kidney cell line transfected with human Calcitonin R
    Ala25-Ala474
    Accession # NP_001733
  • Formulation
    Supplied in a saline solution containing BSA and Sodium Azide.
  • Label
    Allophycocyanin
Applications
  •  
    Recommended
    Concentration
    Sample
  • Flow Cytometry
    10 µL/106 cells
    See below
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Data Examples
Detection of Calcitonin R in MCF‑7 Human Cell Line by Flow Cytometry. MCF‑7 human breast cancer cell line was stained with Mouse Anti-Human Calcitonin R APC‑conjugated Monoclonal Antibody (Catalog # FAB4614A, filled histogram) or isotype control antibody (Catalog # IC003A, open histogram). View our protocol for Staining Membrane-associated Proteins.
Preparation and Storage
  • Shipping
    The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
  • Stability & Storage
    Protect from light. Do not freeze.
    • 12 months from date of receipt, 2 to 8 °C as supplied.
Background: Calcitonin R

Calcitonin Receptor (CALCR) is a glycosylated 55-67 kDa seven-transmembrane G protein-coupled receptor that belongs to the GPCR2 (or Secretin) family of proteins. Alone, CALCR binds Calcitonin, the 32 amino acid (aa) founding member of the 5-member Calcitonin family of peptides. When complexed with RAMP family molecules (RAMP-1, -2, or -3), it serves as a receptor for Amylin. CALCR activation inhibits osteoclast-mediated bone resorption and enhances renal calcium excretion. CALCR polymorphisms and mutations have been associated with several bone disorders. Alternative splicing results in an isoform showing an alternate start at Met19. The construct used for antibody production starts at Ala25 of the short form or Ala43 of the full-length form. Human CALCR shares 70%‑72% aa sequence identity with mouse and rat CACLR.

  • Long Name:
    Calcitonin Receptor
  • Entrez Gene IDs:
    799 (Human); 12311 (Mouse); 116506 (Rat)
  • Alternate Names:
    Calcitonin R; calcitonin receptor; CalcitoninR; CALCR; CRT; CTR; CT-R; CTR1
Related Research Areas

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