Human CLEC2L Alexa Fluor™ Plus 405‑conjugated Antibody

R&D Systems | Catalog # FAB10204AFP405

R&D Systems

Key Product Details

Species Reactivity

Human

Applications

Flow Cytometry

Label

Alexa Fluor Plus 405 (Excitation = 404 nm, Emission = 455 nm)

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # 2326G
View all CLEC2L Primary Antibodies »

Product Specifications

Specificity

Detects human CLEC2L in direct ELISA.

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Applications for Human CLEC2L Alexa Fluor™ Plus 405‑conjugated Antibody

Application
Recommended Usage

Flow Cytometry

Optimal dilution of this antibody should be experimentally determined.

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Flow Cytometry

Formulation, Preparation, and Storage

Formulation

Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: CLEC2L

C-type lectin domain family 2, member L (CLEC2L), is a type II transmembrane protein of the CLEC2 family of proteins that includes CD69, LLT1, AICL and KACL (1, 2). CLEC2 family members have broad tissue expression, with LLT1, AICL and KACL expressed on B cells, monocytes, and keratinocytes, respectively (3-5). In contrast, CLEC2L, a homodimeric cell surface receptor, is predominantly expressed in the brain and is referred to as the brain-associated C-type lectin (BACL) (6). Mature human CLEC2L includes a 68 amino acid (aa) cytoplasmic domain, a 21 aa transmembrane segment, and a 125 aa extracellular domain (ECD). Within the ECD, human CLEC2L shares 94% aa sequence identity with mouse and rat CLEC2L. Our assay shows that CLEC2L binds to Galectin-3.

References

  1. Yokoyama, W.M. and B.F. Plougastel (2003) Nat. Rev. Immunol. 3:304.
  2. Vogler, I. and A. Steinle (2011) J. Innate Immune. 3:227.
  3. Welte, S. et al. (2006) Nat. Immunol. 7:1334.
  4. Spreu, J. et al. (2010) Proc. Natl. Acad. Sci. USA 107:5100.
  5. Rosen, D.B. et al. (2008) J. Immunol. 180:6508.
  6. Lysenko, O. et al. (2013) PloS One. 8:e65345.

Long Name

C-type Lectin Domain Family 2, Member L

Alternate Names

C-type lectin domain family 2 member L, C-type lectin domain family 2, member L

Entrez Gene IDs

154790 (Human); 665180 (Mouse); 296985 (Rat)

Gene Symbol

CLEC2L

UniProt

P0C7M8-1

Additional CLEC2L Products

Product Documents for Human CLEC2L Alexa Fluor™ Plus 405‑conjugated Antibody

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

Product Specific Notices for Human CLEC2L Alexa Fluor™ Plus 405‑conjugated Antibody


This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

For research use only

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