Human DC-LAMP Lumenal Domain PE-conjugated Antibody

FAB4087P has been discontinued. View all DC-LAMP products.
  
  • Species Reactivity
    Human
  • Specificity
    Detects human DC‑LAMP Lumenal Domain in direct ELISAs and Western blots. In direct ELISAs, less than 1% cross-reactivity with recombinant human LAMP is observed.
  • Source
    Polyclonal Goat IgG
  • Purification
    Antigen Affinity-purified
  • Immunogen
    Mouse myeloma cell line NS0-derived recombinant human DC‑LAMP Lumenal Domain
    Asp21-Thr381
    Accession # EAW78337
  • Formulation
    Supplied in a saline solution containing BSA and Sodium Azide.
  • Label
    Phycoerythrin
Applications
  •  
    Recommended
    Concentration
    Sample
  • Flow Cytometry
    10 µL/106 cells
    See below
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Data Examples

Detection of DC‑LAMP in Human Mature Dendritic Cells by Flow Cytometry. Human mature dendritic cells were stained with Goat Anti-Human DC‑LAMP Lumenal Domain PE‑conjugated Antigen Affinity-purified Polyclonal Antibody (Catalog # FAB4087P, filled histogram) or isotype control antibody (Catalog # IC108P, open histogram). View our protocol for Staining Membrane-associated Proteins.

Preparation and Storage
  • Shipping
    The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
  • Stability & Storage
    Protect from light. Do not freeze.
    • 12 months from date of receipt, 2 to 8 °C as supplied.
Background: DC-LAMP
DC-LAMP (Dendritic Cell Lysosome-associated Membrane Protein; also known as CD208 and LAMP3) is a 50‑70 kDa member of the LAMP family of proteins. Mature human DC-LAMP is a 389 amino acid (aa) type I transmembrane protein. It has a 254 aa lumenal N‑terminus and a short 14 aa cytoplasmic tail. The molecule is found in type II pneumocytes, interdigitating DC, and various tumors. DC-LAMP serves as a marker of human mature DC, and it may play a role in normal lysosome and endosome function. Over the region used as immunogen, human DC-LAMP shares 72% and 55% aa sequence identity with canine and mouse DC-LAMP, respectively.
  • Long Name:
    Dendritic Cell-lysosome-associated Membrane Glycoprotein
  • Entrez Gene IDs:
    27074 (Human); 239739 (Mouse); 303801 (Rat)
  • Alternate Names:
    CD208 antigen; CD208; DCLAMP; DC-LAMP; DCLAMPDC-lysosome-associated membrane glycoprotein; LAMP; LAMP3; LAMP-3; lysosomal-associated membrane protein 3DC LAMP; lysosome-associated membrane glycoprotein 3; Protein TSC403; TSC403; TSC403CD208
Related Research Areas

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