Human E6AP/E6 Ubiquitin Ligase Kit - p53 Substrate

Name: Human E6AP/E6 Ubiquitin Ligase Kit - p53 Substrate
Brand: R&D Systems
SKU: K-240

R&D Systems | Catalog # K-240

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Citations (1)

Product Documents

Discontinued Product

K-240 has been discontinued. View all E6AP/UBE3A products.

Preparation & Storage
Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Species

Human

Formulation, Preparation, and Storage

Shipping

The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store the unopened product at -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: E6AP/UBE3A

UBE3A encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined.

Long Name

Human Papillomavirus E6-associated Protein

Alternate Names

ANCR, EPVE6AP, HPVE6A, UBE3A

Entrez Gene IDs

7337 (Human); 22215 (Mouse); 361585 (Rat)

Gene Symbol

UBE3A

Additional E6AP/UBE3A Products

Product Documents for Human E6AP/E6 Ubiquitin Ligase Kit - p53 Substrate

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Product Specific Notices for Human E6AP/E6 Ubiquitin Ligase Kit - p53 Substrate

For research use only

Related Research Areas

E3 Ubiquitin Ligases

Citations for Human E6AP/E6 Ubiquitin Ligase Kit - p53 Substrate

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