Human EDNRB Biotinylated Affinity Purified PAb

EDNRB (Endothelin B Receptor) is a member of the beta-family of rhodopsin receptors. It binds endothelin 1, 2, and 3 and is found on endothelial cells where it mediates vasodilation. Mature human EDNRB is a 7-transmembrane glycoprotein that is 416 amino acids (aa) in length. It contains a 75 aa N-terminal extracellular region (aa 27‑101), and a 44 aa C-terminal cytoplasmic domain. There are three EDNRB variants that affect aa 27‑101. One shows a 90 aa N-terminal extension, a second shows the same 90 aa N-terminal substitution coupled with a deletion of aa 268‑398, and a third shows proteolytic cleavage between Arg64-Ser65. Over aa 27‑101, human EDNRB shares 67% and 97% aa sequence identity with mouse and canine EDNRB, respectively.