Human Integrin beta 7 Fluorescein-conjugated Antibody Summary
Accession # P26010
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Detection of Integrin beta 7 in PBMCs Lymphocytes by Flow Cytometry. Human peripheral blood lymphocytes were stained with Mouse Anti-Human Integrin beta 7 Fluorescein-conjugated Monoclonal Antibody (Catalog # FAB4669F, filled histogram) or isotype control antibody (Catalog # IC002F, open histogram). View our protocol for Staining Membrane-associated Proteins.
Preparation and Storage
Background: Integrin beta 7
Human Integrin beta 7 (also Integrin beta P and M290 IEL Ag) is a 120 kDa member of the Integrin beta chain family of molecules. It is a type I transmembrane glycoprotein that contains a 704 amino acid (aa) extracellular domain (ECD) (aa 20‑723) and a 52 aa cytoplasmic tail. The ECD contains one von Willebrand factor A domain (aa 150‑389) and four cysteine‑rich EGF‑like repeats. One splice variant exists that shows a deletion of aa 501‑648. Integrin beta 7 forms a nondisulfide linked heterodimer with alpha 4 and alpha E integrins. alpha 4 beta 7 binds fibronectin, VCAM-1 and MADCAM1, while alpha E beta 7 binds E-cadherin. The ECD of human beta 7 is 87% aa identical to the ECD of mouse beta 7.
Citation for Human Integrin beta 7 Fluorescein-conjugated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
1 Citation: Showing 1 - 1
Decreases in colonic and systemic inflammation in chronic HIV infection after IL-7 administration.
Authors: Sereti I, Estes J, Thompson W, Morcock D, Fischl M, Croughs T, Beq S, Lafaye de Micheaux S, Yao M, Ober A, Wilson E, Natarajan V, Imamichi H, Boulassel M, Lederman M, Routy J
PLoS Pathog, 2014;10(1):e1003890.
Sample Types: Whole Cells
Applications: Flow Cytometry
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