Human Integrin  beta 8 Alexa Fluor® 488-conjugated Antibody

Catalog # Availability Size / Price Qty
FAB4775G-100UG
Human Integrin  beta 8 Alexa Fluor® 488-conjugated Antibody in Flow Cytometry
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Human Integrin  beta 8 Alexa Fluor® 488-conjugated Antibody Summary

Species Reactivity
Human
Specificity
Detects human Integrin beta 8 in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human Integrins beta 1, beta 2, beta 3, beta 4, beta 5, beta 6, beta 7, or recombinant mouse Integrin beta 8 is observed.
Source
Monoclonal Mouse IgG2B Clone # 416922
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
Mouse myeloma cell line NS0-derived recombinant human Integrin beta 8
Glu43-Arg684 (predicted)
Accession # P26012
Formulation
Supplied in a saline solution containing BSA and Sodium Azide.
Label
Alexa Fluor 488 (Excitation= 488 nm, Emission= 515-545 nm)

Applications

Recommended Concentration
Sample
Flow Cytometry
0.25-1 µg/106 cells
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Data Example

Flow Cytometry Detection of Integrin beta 8 in WM-115 Cell Line by Flow Cytometry. View Larger

Detection of Integrin beta 8 in WM-115 Cell Line by Flow Cytometry. WM-115 human melanoma cell line was stained with Mouse Anti-Human Integrin beta 8 Alexa Fluor® 488-conjugated Monoclonal Antibody (Catalog # FAB4775G, filled histogram) or isotype control antibody (Catalog # IC0041G, open histogram). View our protocol for Staining Membrane-associated Proteins.

Reconstitution Calculator

Reconstitution Calculator

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Preparation and Storage

Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.

Background: Integrin beta 8

Integrin beta 8 (Integrin beta 8) is a 90 kDa type I transmembrane glycoprotein of the Integrin family of adhesion molecules. It associates with Integrin alpha V to form a receptor for vitronectin, fibrin, and the latency associated peptide (LAP). Binding to LAP promotes the proteolytic release of active TGF-beta from LAP. Integrin alpha V beta 8 is required for vascular morphogenesis in the embryonic brain and yolk sac. Within the extracellular domain, human Integrin  beta 8 shares 87% aa sequence identity with mouse and rat Integrin  beta 8.

Entrez Gene IDs
3696 (Human); 320910 (Mouse); 362800 (Rat)
Alternate Names
Integrin beta 8; integrin beta-8; integrin, beta 8; ITGB8

Product Datasheets

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