Human ISG15 Polyclonal Ab

Name: Human ISG15 Polyclonal Ab
Brand: R&D Systems
SKU: A-600
Price: 202 USD

Catalog #: A-600 Datasheet / COA / SDS

Product is in the process of being discontinued

Discontinued Product

A-600 has been discontinued.

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Human ISG15 Polyclonal Ab Summary

Species Reactivity

Human

Specificity

Detects ISG15 and ISG15-protein conjugates in Western blot. The antibody cross-reacts with human ubiquitin and Nedd8, but not SUMO proteins.

Source

Polyclonal Rabbit IgG

Immunogen

Full-length recombinant human ISG15/UCRP

Formulation

Boston Bio will fill in the Formulation info

Applications

Recommended Concentration

Sample

Western Blot

Recommended dilution range for Western blotanalysis is 1:500 to 1:1000. At adilution of 1:1000, 100 ng of monomeric ISG15 can be detected.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store unopened vial at -80°C. Avoid repeated freeze-thaw cycles. Aliquot antibody in small volumes prior to freezing.

Background: ISG15/UCRP

The ubiquitin-like ISG15 acts similar to ubiquitin and is conjugated to intracellular target proteins after IFN-alpha / beta stimulation or microbial challenge. The functions or biochemical consequences ISG15 conjugation to proteins are not yet known, but it appears that this modification does not target proteins for proteasomal degradation.

Long Name

ISG15 Ubiquitin-like Modifier

Entrez Gene IDs

9636 (Human); 100038882 (Mouse); 298693 (Rat)

Alternate Names

G1P2; G1P2interferon-induced 17-kDa/15-kDa protein; IFI15; IFI15hUCRP; interferon, alpha-inducible protein (clone IFI-15K); Interferon-induced 15 kDa protein; Interferon-induced 17 kDa protein; interferon-stimulated protein, 15 kDa; IP17; ISG15 ubiquitin-like modifier; ISG15; Ubiquitin cross-reactive protein; ubiquitin-like protein ISG15; UCRP; UCRPIP17