Human ITCH/AIP4 Ubiquitin Ligase Kit

Name: Human ITCH/AIP4 Ubiquitin Ligase Kit
Brand: R&D Systems
SKU: K-270

R&D Systems | Catalog # K-270

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Citations (1)

Product Documents

Discontinued Product

K-270 has been discontinued. View all ITCH/AIP4 products.

Preparation & Storage
Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Species

Human

Formulation, Preparation, and Storage

Shipping

The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store the unopened product at -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: ITCH/AIP4

Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. The protein encoded by this gene interacts with atrophin-1. This encoded protein is a closely related member of the NEDD4-like protein family. This family of proteins are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. This encoded protein contains four tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. It can act as a transcriptional corepressor of p45/NFE2 and may participate in the regulation of immune responses by modifying Notch-mediated signaling. It is highly similar to the mouse Itch protein, which has been implicated in the regulation and differentiation of erythroid and lymphoid cells.

Long Name

Itchy E3 Ubiquitin Protein Ligase

Alternate Names

AIF4, AIP4, NAPP1

Entrez Gene IDs

83737 (Human); 16396 (Mouse); 311567 (Rat)

Gene Symbol

ITCH

Additional ITCH/AIP4 Products

Product Documents for Human ITCH/AIP4 Ubiquitin Ligase Kit

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Product Specific Notices for Human ITCH/AIP4 Ubiquitin Ligase Kit

For research use only

Related Research Areas

E3 Ubiquitin Ligases

Notch Pathway

Citations for Human ITCH/AIP4 Ubiquitin Ligase Kit

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