Human ITFG1 APC‑conjugated Antibody

R&D Systems | Catalog # FAB89001A

R&D Systems
Discontinued Product
FAB89001A has been discontinued. View all ITFG1 products.

Key Product Details

Species Reactivity

Human

Applications

Flow Cytometry

Label

Allophycocyanin (Excitation = 620-650 nm, Emission = 660-670 nm)

Antibody Source

Monoclonal Mouse IgG2B Clone # 936213
View all ITFG1 Primary Antibodies »

Product Specifications

Immunogen

Human embryonic kidney cell line HEK293-derived human ITFG1
Met1-Ile566
Accession # Q8TB96

Specificity

Detects human ITFG1 in direct ELISAs.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2B

Scientific Data Images for Human ITFG1 APC‑conjugated Antibody

Detection of ITFG1 antibody in K562 Human Cell Line antibody by Flow Cytometry.

Detection of ITFG1 in K562 Human Cell Line by Flow Cytometry.

K562 human chronic myelogenous leukemia cell line was stained with Mouse Anti-Human ITFG1 APC-conjugated Monoclonal Antibody (Catalog # FAB89001A, filled histogram) or isotype control antibody (Catalog # IC0041A, open histogram). View our protocol for Staining Membrane-associated Proteins.

Applications for Human ITFG1 APC‑conjugated Antibody

Application
Recommended Usage

Flow Cytometry

10 µL/106 cells
Sample: K562 human chronic myelogenous leukemia cell line

Spectra Viewer

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Flow Cytometry

Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Formulation

Supplied in a saline solution containing BSA and Sodium Azide.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.

Background: ITFG1

Integrin-alpha FG-GAP repeat-containing protein 1 (ITFG1), also known as T cell immunomodulatory protein (TIP), was initially identified using bioinformatics and high-throughput cell-based screening assays to isolate novel factors involved in T cell biology.  Ubiquitously expressed as a 96-100 kDa glycoprotein (it is absent on T cells, B cells, and monocytes), ITFG1 would appear to be a type I transmembrane protein that contains a 534 amino acids (aa) N-terminal ECD coupled to a 45 aa C-terminal transmembrane and cytoplasmic domain. Both soluble and transmembrane forms of the ITFG1 appear to exist. Human and mouse T cells treated with ITFG1 in vitro secreted the cytokines IFN-gamma, TNF-alpha and IL-10, while in vivo, ITFG1 was protective in a mouse acute graft-versus-host disease (GVHD) model. Based on invertebrate models, human ITFG1 likely serves as a cell adhesion molecule under certain circumstances. Over aa 1-566, human ITFG1 shares 89% and 88% aa sequence identity with mouse and rat ITFG1, respectively.

Long Name

Integrin Alpha FG-GAP Repeat Containing 1

Alternate Names

CDA08, TIP

Entrez Gene IDs

81533 (Human); 71927 (Mouse); 171083 (Rat)

Gene Symbol

ITFG1

UniProt

Q8TB96

Additional ITFG1 Products

Product Documents for Human ITFG1 APC‑conjugated Antibody

Certificate of Analysis

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Product Specific Notices for Human ITFG1 APC‑conjugated Antibody

For research use only

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