Key Product Details

Species Reactivity

Human

Applications

Intracellular Staining by Flow Cytometry

Label

Allophycocyanin (Excitation = 620-650 nm, Emission = 660-670 nm)

Antibody Source

Monoclonal Mouse IgG1 Clone # 35409
View all Latent TGF-beta bp1 Primary Antibodies »

Product Specifications

Immunogen

Human platelet-derived large latent TGF-beta 1 complex

Specificity

Detects human LTBP-1 from the large latent TGF-beta 1 complex.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Scientific Data Images for Human Latent TGF‑ beta  bp1 APC‑conjugated Antibody

Detection of Latent TGF-beta bp1 antibody in PC-3 Human Cell Line antibody by Flow Cytometry.

Detection of Latent TGF‑ beta bp1 in PC‑3 Human Cell Line by Flow Cytometry.

PC-3 human prostate cancer cell line was stained with Mouse Anti-Human Latent TGF-beta bp1 APC-conjugated Monoclonal Antibody (Catalog # IC388A, filled histogram) or isotype control antibody (Catalog # IC002A, open histogram). View our protocol for Staining Intracellular Molecules.

Applications for Human Latent TGF‑ beta  bp1 APC‑conjugated Antibody

Application
Recommended Usage

Intracellular Staining by Flow Cytometry

10 µL/106 cells
Sample: PC‑3 human prostate cancer cell line fixed with Flow Cytometry Fixation Buffer (Catalog # FC004) and permeabilized with Flow Cytometry Permeabilization/Wash Buffer I (Catalog # FC005)

Spectra Viewer

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Flow Cytometry

Formulation, Preparation, and Storage

Purification

Protein A or G purified from ascites

Formulation

Supplied in a saline solution containing BSA and Sodium Azide.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store the unopened product at 2 - 8° C. Do not use past expiration date. Protect from light.

Background: Latent TGF-beta bp1

TGF-beta  is synthesized as high molecular weight latent complexes. In platelets, the large latent TGF-beta 1 complex is composed of three components: mature TGF-beta 1 dimer; latency associated peptide; and a latent TGF-beta binding protein (LTBP) (1-3).The cDNAs for four binding proteins (LTBP-1, -2, -3 and -4) have now been cloned (4-5).

References

  1. Miyazono, K. et al. (1991) EMBO J. 10:1091.
  2. Moren, A. et al. (1994) J. Biol. Chem. 269:32469.
  3. Yin, W. et al. (1995) J. Biol. Chem. 270:10147.
  4. Kanzaki, T. et al. (1990) Cell 61:1051.
  5. Saharinen, J. et al. (1998) J. Biol. Chem. 273:18459.

Alternate Names

Latent TGFbeta bp1, LTBP1

Entrez Gene IDs

4052 (Human)

Gene Symbol

LTBP1

Additional Latent TGF-beta bp1 Products

Product Documents for Human Latent TGF‑ beta  bp1 APC‑conjugated Antibody

Certificate of Analysis

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Product Specific Notices for Human Latent TGF‑ beta  bp1 APC‑conjugated Antibody

For research use only

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