Detection of Latent TGF‑ beta bp1 in PC‑3 Human Cell Line by Flow Cytometry.
PC‑3 human prostate cancer cell line was stained with Mouse Anti-Human Latent TGF‑ beta bp1 APC‑conjugated Monoclonal Antibody (Catalog # IC388A, filled histogram) or isotype control antibody (Catalog # IC002A, open histogram). View our protocol for Staining Intracellular Molecules.
Preparation and Storage
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze.
12 months from date of receipt, 2 to 8 °C as supplied.
Background: Latent TGF-beta bp1
TGF-beta is synthesized as high molecular weight latent complexes. In platelets, the large latent TGF-beta 1 complex is composed of three components: mature TGF-beta 1 dimer; latency associated peptide; and a latent TGF-beta binding protein (LTBP) (1-3).The cDNAs for four binding proteins (LTBP-1, -2, -3 and -4) have now been cloned (4-5).
Miyazono, K. et al. (1991) EMBO J. 10:1091.
Moren, A. et al. (1994) J. Biol. Chem. 269:32469.
Yin, W. et al. (1995) J. Biol. Chem. 270:10147.
Kanzaki, T. et al. (1990) Cell 61:1051.
Saharinen, J. et al. (1998) J. Biol. Chem. 273:18459.
Entrez Gene IDs:
Latent TGFbeta bp1; Latent TGF-beta bp1; latent transforming growth factor beta binding protein 1; latent-transforming growth factor beta-binding protein 1; LTBP1; LTBP-1; MGC163161; TGF-beta1-BP-1; Transforming growth factor beta-1-binding protein 1
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