Human/Mouse/Rat FKBP38 Alexa Fluor® 488-conjugated Antibody

Catalog #: FAB3580G Datasheet / COA / SDS

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FAB3580G-100UG

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Human/Mouse/Rat FKBP38 Alexa Fluor® 488-conjugated Antibody Summary

Species Reactivity

Human, Mouse, Rat

Specificity

Detects endogenous human, mouse and rat FKBP38 in Western blots.

Source

Monoclonal Mouse IgG2b Clone # 391505

Purification

Protein A or G purified

Immunogen

E. coli-derived recombinant human FKBP38
Met58-Gly382
Accession # Q14318

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 488 (Excitation= 488 nm, Emission= 515-545 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: FKBP38

FK506 Binding Proteins (FKBPs) are intracellular receptors for the immuno-suppressive drug FK506. The FKBP/FK506 complex exerts its immunosuppressive effects by inhibiting calcineurin, a calcium- and calmodulin-dependent serine/threonine phosphatase that functions as a critical signaling molecule during T-cell activation. FKBP38, also known as FKBP8, is a 355 to 412 amino acid (aa) protein with an apparent molecular mass of ~60‑64 kDa in SDS-PAGE. FKBP38 binds to and inhibits calcineurin even in the absence of FK506, indicating that FKBP38 is a constitutively active inhibitor of calcineurin. Additionally, FKBP38 co‑immunoprecipitates with Bcl-2 and Bcl-xL, suggesting that FKBP38 may regulate apoptosis by anchoring Bcl‑2 and Bcl‑xL to mitochondrial membranes. Mouse FKBP38 shares 94% and 87% sequence identity with human and rat FKBP38, respectively.

Long Name

38 kDa FK506 Binding Protein

Entrez Gene IDs

23770 (Human); 14232 (Mouse); 290652 (Rat)

Alternate Names

38 kDa FK506-binding protein; EC 5.2.1.8,38 kDa FKBP; FK506 binding protein 8, 38kDa; FK506-binding protein 8 (38kD); FK506-binding protein 8; FKBP38; FKBP-38; FKBP38PPIase FKBP8; FKBP8; FKBP-8; FKBPr38; hFKBP38; peptidyl-prolyl cis-trans isomerase FKBP8; rotamase