Human/Mouse/Rat PTP gamma /PTPRG Antibody

R&D Systems | Catalog # MAB4608

R&D Systems
Discontinued Product
MAB4608 has been discontinued. View all PTP gamma/PTPRG products.

Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Cited:

Human, Mouse

Applications

Validated:

Western Blot

Cited:

Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2B Clone # 481505
View all PTP gamma/PTPRG Primary Antibodies »

Product Specifications

Immunogen

E. coli-derived recombinant human PTP gamma /PTPRG
Ser111-Ala541
Accession # P23470

Specificity

Detects human, mouse, and rat PTP gamma /PTPRG in Western blots. In Western blots, no cross-reactivity with recombinant human PTPRM, PTPRK, PTPRS, LAR, or DEP1 is observed.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2B

Scientific Data Images for Human/Mouse/Rat PTP gamma /PTPRG Antibody

Detection of Human and Mouse PTP?/PTPRG antibody by Western Blot.

Detection of Human and Mouse PTP gamma /PTPRG by Western Blot.

Western blot shows lysates of CHP-100 human neuroblastoma cell line, SH-SY5Y human neuroblastoma cell line, and Neuro-2A mouse neuroblastoma cell line. PVDF membrane was probed with 1 µg/mL of Mouse Anti-Human/Mouse/Rat PTP gamma/PTPRG Monoclonal Antibody (Catalog # MAB4608) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF007). A specific band was detected for PTP gamma/PTPRG at approximately 160 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 2.

Applications for Human/Mouse/Rat PTP gamma /PTPRG Antibody

Application
Recommended Usage

Western Blot

1 µg/mL
Sample: CHP-100 human neuroblastoma cell line, SH-SY5Y human neuroblastoma cell line, and Neuro-2A mouse neuroblastoma cell line

Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Calculators

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: PTP gamma/PTPRG

Protein Tyrosine Phosphatase, Receptor type gamma (PTPR gamma ), also called PTPRG and PTPG, is a transmembrane protein. Its extracellular region contains carbonic anhydrase fibronectin III domains, suggesting that it interacts with adhesion molecules, but the only reported activator is an intracellular ATP-dependent factor. During brain development, PTPR gamma is found exclusively in post-mitotic neurons. A wide variety of cancers, including colon, renal clear cell, lung, breast, and cervical cancers, show a high incidence of defects in the PTPR gamma gene, suggesting the protein has a key regulatory function in tumor suppression.

Long Name

Protein Tyrosine Phosphatase Receptor-type Gamma

Alternate Names

PTPG, PTPRG

Entrez Gene IDs

5793 (Human); 19270 (Mouse); 171357 (Rat)

Gene Symbol

PTPRG

UniProt

P23470

Additional PTP gamma/PTPRG Products

Product Documents for Human/Mouse/Rat PTP gamma /PTPRG Antibody

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Note: Certificate of Analysis not available for kit components.

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Product Specific Notices for Human/Mouse/Rat PTP gamma /PTPRG Antibody

For research use only

Related Research Areas

Epigenetics
Phosphatases and Regulators

Citations for Human/Mouse/Rat PTP gamma /PTPRG Antibody

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