Detection of Human and Mouse PTP gamma /PTPRG by Western Blot.
Western blot shows lysates of CHP‑100 human neuroblastoma cell line, SH‑SY5Y human neuroblastoma cell line, and Neuro‑2A mouse neuroblastoma cell line. PVDF membrane was probed with 1 µg/mL of Mouse Anti-Human/Mouse/Rat PTP gamma /PTPRG Monoclonal Antibody (Catalog # MAB4608) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF007). A specific band was detected for PTP gamma /PTPRG at approximately 160 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 2.
Preparation and Storage
Reconstitute at 0.5 mg/mL in sterile PBS.
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: PTP gamma/PTPRG
Protein Tyrosine Phosphatase, Receptor type gamma (PTPR gamma ), also called PTPRG and PTPG, is a transmembrane protein. Its extracellular region contains carbonic anhydrase fibronectin III domains, suggesting that it interacts with adhesion molecules, but the only reported activator is an intracellular ATP-dependent factor. During brain development, PTPR gamma is found exclusively in post-mitotic neurons. A wide variety of cancers, including colon, renal clear cell, lung, breast, and cervical cancers, show a high incidence of defects in the PTPR gamma gene, suggesting the protein has a key regulatory function in tumor suppression.
Protein Tyrosine Phosphatase Receptor-type Gamma
Entrez Gene IDs:
5793 (Human); 19270 (Mouse); 171357 (Rat)
EC 220.127.116.11; H_RG317H01.1; HPTPG; protein tyrosine phosphatase, receptor type, G; protein tyrosine phosphatase, receptor type, gamma polypeptide; Protein-tyrosine phosphatase gamma; PTP gamma; PTPG; PTPGprotein tyrosine phosphatase gamma; PTPRG; receptor type protein tyrosine phosphatase gamma; receptor tyrosine phosphatase gamma; receptor-type protein phosphatase gamma; receptor-type tyrosine-protein phosphatase gamma; RPTPG; R-PTP-GAMMA
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