Human NAC1 Alexa Fluor® 750-conjugated Antibody

Catalog #: AF8375S Datasheet / COA / SDS

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AF8375S-100UG

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Human NAC1 Alexa Fluor® 750-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human NAC1 in direct ELISAs and Western Blots. In direct ELISAs, appoximately 100% cross-reactivity with recombinant mouse NAC1 is observed.

Source

Polyclonal Sheep IgG

Purification

Antigen Affinity-purified

Immunogen

E. coli-derived recombinant human NAC1
Val471-Gln527
Accession # Q96RE7

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 750 (Excitation= 749 nm, Emission= 775 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Knockout Validated

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: NAC1

NAC1 (nucleus accumbens-associated protein 1; also NACC1) is a 527 aa BTB/POZ domain containing protein. Human NAC1 shares 86% and 85% aa identity with mouse and rat NAC1, respectively. It has been shown to have a role in transcriptional regulation in both pluripotent stem cells and in the brain. Additionally, NAC1 expression is upregulated in many cancers and this expression has been suggested to correlate with increased aggressiveness in some cancers.

Long Name

Nucleus Accumbens Associated 1

Entrez Gene IDs

112939 (Human); 66830 (Mouse); 171454 (Rat)

Alternate Names

BEND8; BTB (POZ) domain containing 14B; BTB/POZ domain-containing protein 14B; BTBD14B; BTBD30; NAC1; NAC1BEN domain containing 8; NAC-1FLJ37383; NACC1; nucleus accumbens associated 1, BEN and BTB (POZ) domain containing; nucleus accumbens-associated protein 1; transcriptional repressor NAC1