Human Serpin B6 Alexa Fluor™ Plus 488‑conjugated Antibody

R&D Systems | Catalog # AF4336AFP488

R&D Systems
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Key Product Details

Species Reactivity

Human

Applications

Western Blot

Label

Alexa Fluor Plus 488 (Excitation = 493 nm, Emission = 518 nm)

Antibody Source

Polyclonal Sheep IgG
View all Serpin B6 Primary Antibodies »

Product Specifications

Specificity

Detects human Serpin B6 in direct ELISAs and Western blots. In direct ELISAs, less than 5% cross‑reactivity with recombinant human (rh) Serpin B8 and rhSerpin B9 is observed.

Clonality

Polyclonal

Host

Sheep

Isotype

IgG

Applications for Human Serpin B6 Alexa Fluor™ Plus 488‑conjugated Antibody

Application
Recommended Usage

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Formulation

Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: Serpin B6

Serpin B6 (serine protease inhibitor-clade B#6; also placental thrombin inhibitor) is a 42 kDa, cytosolic member of the ovalbumin (clade B)-subfamily, Serpin superfamily of protease inhibitors. It is produced by multiple cell types (keratinocytes; monocytes; mast cells), and shows inhibitory activity towards thrombin, plasmin and chymotrypsin. Human Serpin B6 is 376 amino acids (aa) in length. An active inhibitor site lies between Glu327 and Met338. Multiple potential isoforms exist. One shows a 28 aa substitution for the N-terminal 191 amino acids. Three others have alternate start sites that vary from 14‑33 aa’s upstream of the standard start site. Human Serpin B6 shares 76% aa identity with mouse Serpin B6.

Alternate Names

CAP, PI6, PTI

Entrez Gene IDs

5269 (Human); 20719 (Mouse); 291085 (Rat)

Gene Symbol

SERPINB6

UniProt

P35237

Additional Serpin B6 Products

Product Documents for Human Serpin B6 Alexa Fluor™ Plus 488‑conjugated Antibody

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

Product Specific Notices for Human Serpin B6 Alexa Fluor™ Plus 488‑conjugated Antibody


This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

For research use only

Related Research Areas

Serine Proteases and Regulators

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