Human SLC6A4/5-HTTLPR Alexa Fluor® 350-conjugated Antibody

Catalog #: FAB17292U Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
FAB17292U-100UG
R&D Systems Antibodies
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Human SLC6A4/5-HTTLPR Alexa Fluor® 350-conjugated Antibody Summary

Species Reactivity
Human
Specificity
Detects human SLC6A4/5-HTTLPR in direct ELISAs.
Source
Monoclonal Mouse IgG2A Clone # 632705
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
Human SLC6A4/5-HTTLPR synthetic peptide
Accession # P31645
Formulation
Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.
Label
Alexa Fluor 350 (Excitation= 346 nm, Emission= 442 nm)

Applications

Recommended Concentration
Sample
Flow Cytometry
Titration recommended for optimal concentration with starting range of 0.1-1 µg/1 million cells. Samples used for this experiment was HEK293 Human Cell Line Transfected with Human SLC6A4/5-HTTLPR and eGFP.
 

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.

Background: SLC6A4/5-HTTLPR

SLC6A4 is an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into pre-synaptic neurons. It terminates the action of serotonin and recycles it in a sodium-dependent manner. A repeat length polymorphism in the promoter of SLC6A4 has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients,and depression-susceptibility in people experiencing emotional trauma.

Long Name
Solute Carrier Family 6 Member 4
Entrez Gene IDs
6532 (Human); 15567 (Mouse); 25553 (Rat)
Alternate Names
5HT transporter; 5-HT Transporter; 5-HTT; 5HTTLPR; 5-HTTLPR; hSERT; HTT5-hydroxytryptamine transporter; Na+/Cl- dependent serotonin transporter; OCD1; Serotonin Transporter 1; SERT; SLC6A4; sodium-dependent serotonin transporter; solute carrier family 6 (neurotransmitter transporter, serotonin), member 4,5-HTTLPR; Solute carrier family 6 member 4,5HTT

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Product Specific Notices


This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.

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