Human SUMO2/3 Antibody

Catalog # Availability Size / Price Qty
A-724
Product Details
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Human SUMO2/3 Antibody Summary

Source
Monoclonal Rat IgG1 Clone # 401504
Immunogen
Purified, recombinant human SUMO3
Accession # P55854
Formulation
Supplied as a solution in PBS containing Glycerol and Sodium Azide.

Applications

Recommended Concentration
Sample
Immunoprecipitation
Please refer to the PDF datasheet for specifications.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: SUMO2/3

Small Ubiquitin­like Modifiers (SUMOs) are a family of small, related proteins that can be enzymatically attached to a target protein by a post­translational modification process termed SUMOylation. Unlike ubiquitination, which targets proteins for degradation, SUMOylation participates in a number of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. All human SUMO proteins share a conserved ubiquitin-like domain and a C-terminal diglycine cleavage/attachment site. Human SUMO1, SUMO2, SUMO3, and SUMO4 are all translated as propeptides, containing C-terminal prosegments following the diglycine motif that marks the end of the mature forms. Following prosegment cleavage, SUMO1, 2, and 3 may then be enzymatically attached to a lysine on a target protein. It is not clear whether SUMO4 is processed in a similar fashion.

Long Name
Small Ubiquitin-like Modifier 2, & 3
Alternate Names
HSMT3; small ubiquitin-like modifier 2; SMT3A; SMT3B; SMT3H2; SUMO2; SUMO2/3; SUMO3

Product Datasheets

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