Human TIMP-1 Quantikine ELISA Kit

  (63 citations)   
Product Details
Assay Procedure
Citations (63)
FAQs
Supplemental Products
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  • Assay Type
    Solid Phase Sandwich ELISA
  • Format
    96-well strip plate
  • Assay Length
    3.5 hours
  • Sample Type & Volume Required Per Well
    Cell Culture Supernates (10 uL), Serum (10 uL), EDTA Plasma (10 uL), Heparin Plasma (10 uL), Saliva (10 uL)
  • Sensitivity
    0.08 ng/mL
  • Assay Range
    0.2 - 10 ng/mL (Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma, Saliva)
  • Specificity
    Natural and recombinant human TIMP-1
  • Cross-reactivity
    < 0.5% cross-reactivity observed with available related molecules.Cross-species reactivity not tested.
  • Interference
    Interference observed with 1 or more available related molecules.
Control Available
QC173 , Quantikine Immunoassay Control Set 651 for Human TIMP-1 - Please Inquire
Product Summary
The Quantikine Human TIMP-1 Immunoassay is a 3.5 hour solid phase ELISA designed to measure TIMP-1 concentrations in cell culture supernates, serum, plasma, and saliva. It contains NS0-expressed recombinant human TIMP-1 and antibodies raised against the recombinant factor. It has been shown to quantitate recombinant human TIMP-1 accurately. Results obtained using natural TIMP-1 showed linear curves that were parallel to the standard curve obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural TIMP-1.

Precision
Intra-Assay Precision (Precision within an assay) Three samples of known concentration were tested on one plate to assess intra-assay precision.
Inter-Assay Precision (Precision between assays) Three samples of known concentration were tested in separate assays to assess inter-assay precision.
Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma, Saliva
Intra-Assay Precision Inter-Assay Precision
Sample 1 2 3 1 2 3
n 20 20 20 40 40 40
Mean 0.48 1.27 6.95 0.51 1.28 6.9
Standard Deviation 0.02 0.05 0.35 0.02 0.05 0.34
CV% 4.2 3.9 5 3.9 3.9 4.9

Recovery

The recovery of TIMP-1 spiked to three different levels in samples throughout the range of the assay in various matrices was evaluated.

Sample Type Average % Recovery Range %
Cell Culture Media (n=5) 102 94-113
EDTA Plasma (n=5) 99 93-108
Heparin Plasma (n=5) 99 89-108
Saliva (n=4) 105 89-121
Serum (n=5) 98 87-102
Linearity
To assess the linearity of the assay, samples containing or spiked with high concentrations of TIMP-1 were diluted with Calibrator Diluent to produce samples with values within the dynamic range of the assay.
Human TIMP-1 Quantikine ELISA Kit
Preparation and Storage
  • Storage
    Store the unopened product at 2 - 8 °C. Do not use past expiration date.
Background: TIMP-1
TIMPs-1 through -4 regulate the activity of zinc metalloproteases known as MMPs, ADAMs and ADAMTSs. Structurally, TIMPs contain two domains. The N-terminal domain binds to the active site of mature metalloproteases via a 1:1 non-covalent interaction, blocking access of substrates to the catalytic site. In addition, The C-terminal domain of TIMP-1 and TIMP-2 binds to the hemopexin- like domain of pro-MMP-9 and pro-MMP-2, respectively. The latter binding is essential for the cell surface activation of MMP-2 by MMP-14.
  • Long Name:
    Tissue Inhibitors of Metalloproteinases 1
  • Entrez Gene IDs:
    7076 (Human); 21857 (Mouse); 116510 (Rat)
  • Alternate Names:
    CLGI; Collagenase inhibitor; collagenase inhibitor); EPATIMP-1; EPO; erythroid potentiating activity; Erythroid-potentiating activity; Fibroblast collagenase inhibitor; FLJ90373; HCI; metalloproteinase inhibitor 1; TIMP metallopeptidase inhibitor 1; TIMP1; TIMP-1; TIMPtissue inhibitor of metalloproteinase 1 (erythroid potentiating activity; Tissue inhibitor of metalloproteinases 1
Related Research Areas
Assay Procedure
Refer to the product for complete assay procedure.

Bring all reagents and samples to room temperature before use. It is recommended that all samples, standards, and controls be assayed in duplicate.
  1.   Prepare all reagents, standard dilutions, and samples as directed in the product insert.
  2.   Remove excess microplate strips from the plate frame, return them to the foil pouch containing the desiccant pack, and reseal.

  3. 100 µL Assay Diluent
  4.   Add 100 µL of Assay Diluent to each well.

  5. 50 µL Standard, Control, or Sample
  6.   Add 50 µL of Standard, control, or sample to each well. Cover with a plate sealer, and incubate at room temperature for 2 hours on a horizontal orbital microplate shaker.
  7.   Aspirate each well and wash, repeating the process twice for a total of 3 washes.

  8. 200 µL Conjugate
  9.   Add 200 µL of Conjugate to each well. Cover with a new plate sealer, and incubate at room temperature for 1 hour on the shaker.
  10.   Aspirate and wash 3 times.

  11. 200 µL Substrate Solution
  12.   Add 200 µL Substrate Solution to each well. Incubate at room temperature for 30 minutes on the benchtop. PROTECT FROM LIGHT.

  13. 50 µL Stop Solution
  14.   Add 50 µL of Stop Solution to each well. Read at 450 nm within 30 minutes. Set wavelength correction to 540 nm or 570 nm.
Citations:

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

63 Citations: Showing 1 - 10
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Species
Sample Type
  1. Cerebrospinal fluid matrix metalloproteinase 9 levels, blood-brain barrier permeability, and treatment outcome in tuberculous meningitis
    Authors: S Mailankody, GV Dangeti, R Soundraval, NM Joseph, J Mandal, TK Dutta, T Kadhiravan
    PLoS ONE, 2017;12(7):e0181262.
    Species: Human
    Sample Type: CSF
  2. Collagen turnover biomarkers and systemic right ventricle remodeling in adults with previous atrial switch procedure for transposition of the great arteries
    Authors: M Lipczy?ska, P Szyma?ski, M Kumor, A Klisiewicz, P Hoffman
    PLoS ONE, 2017;12(8):e0180629.
    Species: Human
    Sample Type: Serum
  3. TIMP1 and MMP9 are predictors of mortality in septic patients in the emergency department and intensive care unit unlike MMP9/TIMP1 ratio: Multivariate model
    Authors: ME Niño, SE Serrano, DC Niño, DM McCosham, ME Cardenas, VP Villareal, M Lopez, A Pazin-Filh, FA Jaimes, F Cunha, R Schulz, D Torres-Due
    PLoS ONE, 2017;12(2):e0171191.
    Species: Human
    Sample Type: Serum
  4. Relationship between Serum Levels of Metalloproteinase-8 and Tissue Inhibitor of Metalloproteinases-1 and Exercise Test Results in Postmenopausal Women
    Authors: J Mieczkowsk, E Rutkowska, J Mosiewicz, B Mosiewicz
    Dis. Markers, 2016;2016(0):7169531.
    Species: Human
    Sample Type: Serum
  5. Targeting LOXL2 for cardiac interstitial fibrosis and heart failure treatment
    Nat Commun, 2016;7(0):13710.
    Species: Human
    Sample Type: Plasma
  6. TIMP-1 Inhibits Apoptosis in Lung Adenocarcinoma Cells via Interaction with Bcl-2.
    Authors: Nalluri S, Ghoshal-Gupta S, Kutiyanawalla A, Gayatri S, Lee B, Jiwani S, Rojiani A, Rojiani M
    PLoS ONE, 2015;10(9):e0137673.
    Species: Human
    Sample Type: Cell Culture Supernates
  7. Metallothionein-3 Increases Triple-Negative Breast Cancer Cell Invasiveness via Induction of Metalloproteinase Expression.
    Authors: Kmiecik A, Pula B, Suchanski J, Olbromski M, Gomulkiewicz A, Owczarek T, Kruczak A, Ambicka A, Rys J, Ugorski M, Podhorska-Okolow M, Dziegiel P
    PLoS ONE, 2015;10(5):e0124865.
    Species: Human
    Sample Type: Cell Culture Supernates
  8. Identification and characterization of PDGFRalpha+ mesenchymal progenitors in human skeletal muscle.
    Authors: Uezumi A, Fukada S, Yamamoto N, Ikemoto-Uezumi M, Nakatani M, Morita M, Yamaguchi A, Yamada H, Nishino I, Hamada Y, Tsuchida K
    Cell Death Dis, 2014;5(0):e1186.
    Species: Human
    Sample Type: Cell Culture Supernates
  9. Association between serum tissue inhibitor of matrix metalloproteinase-1 levels and mortality in patients with severe brain trauma injury.
    Authors: Lorente L, Martin M, Lopez P, Ramos L, Blanquer J, Caceres J, Sole-Violan J, Solera J, Cabrera J, Argueso M, Ortiz R, Mora M, Lubillo S, Jimenez A, Borreguero-Leon J, Gonzalez A, Orbe J, Rodriguez J, Paramo J
    PLoS ONE, 2014;9(4):e94370.
    Species: Human
    Sample Type: Serum
  10. Exogenous IFN-beta regulates the RANKL-c-Fos-IFN-beta signaling pathway in the collagen antibody-induced arthritis model.
    Authors: Zhao R, Chen N, Zhou X, Miao P, Hu C, Qian L, Yu Q, Zhang J, Nie H, Chen X, Li P, Xu R, Xiao L, Zhang X, Liu J, Zhang D
    J Transl Med, 2014;12(1):330.
    Species: Human
    Sample Type: Serum
  11. Interleukin-6 and matrix metalloproteinase expression in the subretinal fluid during proliferative vitreoretinopathy: correlation with extent, duration of RRD and PVR grade.
    Authors: Symeonidis C, Papakonstantinou E, Androudi S, Tsaousis KT, Tsinopoulos I, Brazitikos P, Karakiulakis G, Diza E, Dimitrakos SA
    Cytokine, 2012;59(1):184-90.
    Species: Human
    Sample Type: Subretinal Fluid
  12. Validation and quality control of ELISAs for the use with human saliva samples.
    Authors: Jaedicke KM, Taylor JJ, Preshaw PM
    J. Immunol. Methods, 2012;377(1):62-5.
    Species: Human
    Sample Type: Saliva
  13. Tissue inhibitor of matrix metalloproteinase 1 (TIMP1) controls adipogenesis in obesity in mice and in humans.
    Authors: Meissburger B, Stachorski L, Roder E, Rudofsky G, Wolfrum C
    Diabetologia, 2011;54(6):1468-79.
    Species: Human
    Sample Type: Serum
  14. Plasma markers for identifying patients with metastatic melanoma.
    Authors: Kluger HM, Hoyt K, Bacchiocchi A, Mayer T, Kirsch J, Kluger Y, Sznol M, Ariyan S, Molinaro A, Halaban R
    Clin. Cancer Res., 2011;17(8):2417-25.
    Species: Human
    Sample Type: Plasma
  15. Increased levels of leukocyte-derived MMP-9 in patients with stable angina pectoris.
    Authors: Jonasson S, Lundberg A, Kalvegren H, Bergstrom I, Szymanowski A, Jonasson L
    PLoS ONE, 2011;6(4):e19340.
    Species: Human
    Sample Type: Serum
  16. Interleukin-6 and the matrix metalloproteinase response in the vitreous during proliferative vitreoretinopathy.
    Authors: Symeonidis C, Papakonstantinou E, Androudi S, Rotsos T, Diza E, Brazitikos P, Karakiulakis G, Dimitrakos SA
    Cytokine, 2011;54(2):212-7.
    Species: Human
    Sample Type: Vitreous Humor
  17. Biomarkers of extracellular matrix metabolism (MMP-9 and TIMP-1) and risk of stroke, myocardial infarction, and cause-specific mortality: cohort study.
    Authors: Hansson J, Vasan RS, Arnlov J, Ingelsson E, Lind L, Larsson A, Michaelsson K, Sundstrom J
    PLoS ONE, 2011;6(1):e16185.
    Species: Human
    Sample Type: Serum
  18. TLR4 Protein Contributes to Cigarette Smoke-induced Matrix Metalloproteinase-1 (MMP-1) Expression in Chronic Obstructive Pulmonary Disease.
    Authors: Geraghty P, Dabo AJ, D'Armiento J
    J. Biol. Chem., 2011;286(34):30211-8.
    Species: Human
    Sample Type: Cell Culture Supernates
  19. Prognostic significance of TIMP-1 in non-small cell lung cancer.
    Authors: Pesta M, Kulda V, Kucera R
    Anticancer Res., 2011;31(11):4031-8.
    Species: Human
    Sample Type: Plasma
  20. Early Elevation of Matrix Metalloproteinase-8 and -9 in Pediatric ARDS Is Associated with an Increased Risk of Prolonged Mechanical Ventilation.
    Authors: Kong MY, Li Y, Oster R, Gaggar A, Clancy JP
    PLoS ONE, 2011;6(8):e22596.
    Species: Human
    Sample Type: Tissue Secretion
  21. The effect of aspirin desensitization on novel biomarkers in aspirin-exacerbated respiratory diseases.
    Authors: Katial RK, Strand M, Prasertsuntarasai T, Leung R, Zheng W, Alam R
    J. Allergy Clin. Immunol., 2010;126(4):738-44.
    Species: Human
    Sample Type: Sputum
  22. Primary human acute myelogenous leukemia cells release matrix metalloproteases and their inhibitors: release profile and pharmacological modulation.
    Authors: Reikvam H, Hatfield KJ, Oyan AM, Kalland KH, Kittang AO, Bruserud O
    Eur. J. Haematol., 2010;84(3):239-51.
    Species: Human
    Sample Type: Cell Culture Supernates
  23. Plasma tissue inhibitor of matrix metalloproteinase-1 (TIMP-1): an independent predictor of poor response to cardiac resynchronization therapy.
    Authors: Tolosana JM, Mont L, Sitges M, Berruezo A, Delgado V, Vidal B, Tamborero D, Morales M, Batlle M, Roig E, Castel MA, Perez-Villa F, Godoy M, Brugada J
    Eur. J. Heart Fail., 2010;12(5):492-8.
    Species: Human
    Sample Type: Plasma
  24. A multi-analyte serum test for the detection of non-small cell lung cancer.
    Authors: Farlow EC, Vercillo MS, Coon JS, Basu S, Kim AW, Faber LP, Warren WH, Bonomi P, Liptay MJ, Borgia JA
    Br. J. Cancer, 2010;103(8):1221-8.
    Species: Human
    Sample Type: Serum
  25. Plasma haemoxygenase-1 in coronary artery disease. A comparison with angiogenin, matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1 and vascular endothelial growth factor.
    Authors: Idriss NK, Lip GY, Balakrishnan B
    Thromb. Haemost., 2010;104(5):1029-37.
    Species: Human
    Sample Type: Plasma
  26. High matrix metalloproteinase production correlates with immune activation and leukocyte migration in leprosy reactional lesions.
    Authors: Teles RM, Teles RB, Amadeu TP, Moura DF, Mendonca-Lima L, Ferreira H, Santos IM, Nery JA, Sarno EN, Sampaio EP
    Infect. Immun., 2010;78(3):1012-21.
    Species: Human
    Sample Type: Serum
  27. The diagnostic value of matrix metalloproteinase 9 (MMP-9) and tissue inhibitor of matrix metalloproteinases 1 (TIMP-1) determination in the sera of colorectal adenoma and cancer patients.
    Authors: Mroczko B, Groblewska M, Okulczyk B, Kedra B, Szmitkowski M
    Int J Colorectal Dis, 2010;25(10):1177-84.
    Species: Human
    Sample Type: Serum
  28. Matrix metalloproteinase activity in pediatric acute lung injury.
    Authors: Kong MY, Gaggar A, Li Y
    Int J Med Sci, 2009;6(1):9-17.
  29. Matrix metalloproteinase-9, -10, and tissue inhibitor of matrix metalloproteinases-1 blood levels as biomarkers of severity and mortality in sepsis.
    Authors: Lorente L, Martin MM, Labarta L, Diaz C, Sole-Violan J, Blanquer J, Orbe J, Rodriguez JA, Jimenez A, Borreguero-Leon JM, Belmonte F, Medina JC, Lliminana MC, Ferrer-Aguero JM, Ferreres J, Mora ML, Lubillo S, Sanchez M, Barrios Y, Sierra A, Paramo JA
    Crit Care, 2009;13(5):R158.
    Species: Human
    Sample Type: Serum
  30. MMP expression and abnormal lung permeability are important determinants of outcome in IPF.
    Authors: McKeown S, Richter AG, O'Kane C, O'Kane C, McAuley DF, Thickett DR
    Eur. Respir. J., 2009;33(1):77-84.
    Species: Human
    Sample Type: BALF
  31. Protective effects of butanol fraction from Betula Platyphyla var. japonica on cartilage alterations in a rabbit collagenase-induced osteoarthritis.
    Authors: Huh JE, Baek YH, Kim YJ, Lee JD, Choi DY, Park DS
    J Ethnopharmacol, 2009;123(3):515-21.
    Species: Rabbit
    Sample Type: Synovial Fluid
  32. Immunomodulation by chronobiologically-based glucocorticoids treatment for multiple sclerosis relapses.
    Authors: Glass-Marmor L, Paperna T, Galboiz Y, Miller A
    J. Neuroimmunol., 2009;210(1):124-7.
    Species: Human
    Sample Type: Serum
  33. Integrated proteomic analysis of human cancer cells and plasma from tumor bearing mice for ovarian cancer biomarker discovery.
    Authors: Pitteri SJ, JeBailey L, Faca VM, Thorpe JD, Silva MA, Ireton RC, Horton MB, Wang H, Pruitt LC, Zhang Q, Cheng KH, Urban N, Hanash SM, Dinulescu DM
    PLoS ONE, 2009;4(11):e7916.
    Species: Human
    Sample Type: Plasma
  34. Serum matrix metalloproteinases in adult CF patients: Relation to pulmonary exacerbation.
    Authors: Roderfeld M, Rath T, Schulz R, Seeger W, Tschuschner A, Graf J, Roeb E
    J. Cyst. Fibros., 2009;8(5):338-47.
    Species: Human
    Sample Type: Serum
  35. Gingival fibroblast inhibits MMP-7: evaluation in an ex vivo aorta model.
    Authors: Gogly B, Fournier B, Couty L, Naveau A, Brasselet C, Durand E, Coulomb B, Lafont A
    J. Mol. Cell. Cardiol., 2009;47(2):296-303.
    Species: Rabbit
    Sample Type: Cell Culture Supernates
  36. Salbutamol up-regulates matrix metalloproteinase-9 in the alveolar space in the acute respiratory distress syndrome.
    Authors: O'Kane CM, McKeown SW, Perkins GD, Bassford CR, Gao F, Thickett DR, McAuley DF
    Crit. Care Med., 2009;37(7):2242-9.
    Species: Human
    Sample Type: BALF
  37. Impact of acute exposure to tobacco smoke on gelatinases in the bronchoalveolar space.
    Authors: Glader P, Eldh B, Bozinovski S, Andelid K, Sjostrand M, Malmhall C, Anderson GP, Riise GC, Qvarfordt I, Linden A
    Eur. Respir. J., 2008;32(3):644-50.
    Species: Human
    Sample Type: BALF
  38. Use of an immunoaffinity-mass spectrometry-based approach for the quantification of protein biomarkers from serum samples of lung cancer patients.
    Authors: Nicol GR, Han M, Kim J, Birse CE, Brand E, Nguyen A, Mesri M, FitzHugh W, Kaminker P, Moore PA, Ruben SM, He T
    Mol. Cell Proteomics, 2008;7(10):1974-82.
    Species: Human
    Sample Type: Serum
  39. Imbalance of tissue inhibitors of metalloproteinases (TIMP) - 1 and - 4 serum levels, in patients with inflammatory bowel disease.
    Authors: Kapsoritakis AN, Kapsoritaki AI, Davidi IP, Lotis VD, Manolakis AC, Mylonis PI, Theodoridou AT, Germenis AE, Potamianos SP
    BMC Gastroenterol, 2008;8(1):55.
    Species: Human
    Sample Type: Serum
  40. Gene transfer of matrix metalloproteinase-9 induces tumor regression of breast cancer in vivo.
    Authors: Bendrik C, Robertson J, Gauldie J, Dabrosin C
    Cancer Res., 2008;68(9):3405-12.
    Species: Human
    Sample Type: Tissue Homogenates
  41. Activation of the osteopontin/matrix metalloproteinase-9 pathway correlates with prostate cancer progression.
    Authors: Castellano G, Malaponte G, Mazzarino MC, Figini M, Marchese F, Gangemi P, Travali S, Stivala F, Canevari S, Libra M
    Clin. Cancer Res., 2008;14(22):7470-80.
    Species: Human
    Sample Type: Plasma
  42. Matrix metalloproteinase-2 dysregulation in type 1 diabetes.
    Authors: Thrailkill KM, Bunn RC, Moreau CS, Cockrell GE, Simpson PM, Coleman HN, Frindik JP, Kemp SF, Fowlkes JL
    Diabetes Care, 2007;30(9):2321-6.
    Species: Human
    Sample Type: Plasma
  43. Borrelia burgdorferi-induced monocyte chemoattractant protein-1 production in vivo and in vitro.
    Authors: Zhao Z, McCloud B, Fleming R, Klempner MS
    Biochem. Biophys. Res. Commun., 2007;358(2):528-33.
    Species: Human
    Sample Type: Tissue Homogenates
  44. Is metalloproteinase-7 specific for idiopathic pulmonary fibrosis?
    Authors: Huh JW, Kim DS, Oh YM, Shim TS, Lim CM, Lee SD, Koh Y, Kim WS, Kim WD, Kim KR
    Chest, 2007;133(5):1101-6.
    Species: Human
    Sample Type: BALF
  45. Actinobacillus actinomycetemcomitans lipopolysaccharide regulates matrix metalloproteinase, tissue inhibitors of matrix metalloproteinase, and plasminogen activator production by human gingival fibroblasts: a potential role in connective tissue destruction.
    Authors: Bodet C, Andrian E, Tanabe S, Grenier D
    J. Cell. Physiol., 2007;212(1):189-94.
    Species: Human
    Sample Type: Cell Culture Supernates
  46. Tissue engineering for full-thickness burns: a dermal substitute from bench to bedside.
    Authors: Kellouche S, Martin C, Korb G, Rezzonico R, Bouard D, Benbunan M, Dubertret L, Soler C, Legrand C, Dosquet C
    Biochem. Biophys. Res. Commun., 2007;363(3):472-8.
    Species: Human
    Sample Type: Cell Culture Supernates
  47. Airway remodeling and lack of bronchodilator response in steroid-resistant asthma.
    Authors: Goleva E, Hauk PJ, Boguniewicz J, Martin RJ, Leung DY
    J. Allergy Clin. Immunol., 2007;120(5):1065-72.
    Species: Human
    Sample Type: BALF
  48. Oncostatin M induces angiogenesis and cartilage degradation in rheumatoid arthritis synovial tissue and human cartilage cocultures.
    Authors: Fearon U, Mullan R, Markham T, Connolly M, Sullivan S, Poole AR, FitzGerald O, Bresnihan B, Veale DJ
    Arthritis Rheum., 2006;54(10):3152-62.
    Species: Human
    Sample Type: Cell Culture Supernates
  49. A comparison of airway and serum matrix metalloproteinase-9 activity among normal subjects, asthmatic patients, and patients with asthmatic mucus hypersecretion.
    Authors: Ko FW, Diba C, Roth M, McKay K, Johnson PR, Salome C, King GG
    Chest, 2005;127(6):1919-27.
    Species: Human
    Sample Type: Serum
  50. Cell expression of MMP-1 and TIMP-1 in co-cultures of human gingival fibroblasts and monocytes: the involvement of ICAM-1.
    Authors: Domeij H, Modeer T, Quezada HC, Yucel-Lindberg T
    Biochem. Biophys. Res. Commun., 2005;338(4):1825-33.
    Species: Human
    Sample Type: Cell Culture Supernates
  51. Plasma storage at -80 degrees C does not protect matrix metalloproteinase-9 from degradation.
    Authors: Rouy D, Ernens I, Jeanty C, Wagner DR
    Anal. Biochem., 2005;338(2):294-8.
    Species: Human
    Sample Type: Plasma
  52. Induction of host matrix metalloproteinases by Borrelia burgdorferi differs in human and murine lyme arthritis.
    Authors: Behera AK, Hildebrand E, Scagliotti J, Steere AC, Hu LT
    Infect. Immun., 2005;73(1):126-34.
    Species: Human
    Sample Type: Synovial Fluid
  53. Induced sputum matrix metalloproteinase-9 correlates with lung function and airway inflammation in children with cystic fibrosis.
    Authors: Sagel SD, Kapsner RK, Osberg I
    Pediatr. Pulmonol., 2005;39(3):224-32.
    Species: Human
    Sample Type: Sputum
  54. Differential proteolytic enzyme activity in eosinophilic and neutrophilic asthma.
    Authors: Simpson JL, Scott RJ, Boyle MJ, Gibson PG
    Am. J. Respir. Crit. Care Med., 2005;172(5):559-65.
    Species: Human
    Sample Type: Sputum
  55. Plasma MMP-2 and MMP-9 and their inhibitors TIMP-1 and TIMP-2 during human orthotopic liver transplantation. The effect of aprotinin and the relation to ischemia/reperfusion injury.
    Authors: Kuyvenhoven JP, Molenaar IQ, Verspaget HW, Veldman MG, Palareti G, Legnani C, Moolenburgh SE, Terpstra OT, Lamers CB, van Hoek B, Porte RJ
    Thromb. Haemost., 2004;91(3):506-13.
    Species: Human
    Sample Type: Plasma
  56. Determination of the serum matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in patients with either advanced small-cell lung cancer or non-small-cell lung cancer prior to treatment.
    Authors: Jumper C, Cobos E, Lox C
    Respir Med, 2004;98(2):173-7.
    Species: Human
    Sample Type: Serum
  57. Matrix metalloproteinases production in malignant pleural effusions after talc pleurodesis.
    Authors: D&amp;amp;apos;Agostino P
    Clin. Exp. Immunol., 2003;134(1):138-42.
    Species: Human
    Sample Type: Pleural Effusion
  58. Anti-inflammatory cytokine profile in acute coronary syndromes: behavior of interleukin-10 in association with serum metalloproteinases and proinflammatory cytokines.
    Authors: Tziakas DN, Chalikias GK, Hatzinikolaou HI, Parissis JT, Papadopoulos ED, Trypsianis GA, Papadopoulou E, Tentes IK, Karas SM, Hatseras DI
    Int. J. Cardiol., 2003;92(2):169-75.
    Species: Human
    Sample Type: Serum
  59. Matrix metalloproteinases and tissue inhibitors of metalloproteinases in sera and tissue of patients with Dupuytren's disease.
    Authors: Ulrich D, Hrynyschyn K, Pallua N
    Plast. Reconstr. Surg., 2003;112(5):1279-86.
    Species: Human
    Sample Type: Serum
  60. Induced sputum-retrieved matrix metalloproteinase 9 and tissue metalloproteinase inhibitor 1 in granulomatous diseases.
    Authors: Fireman E, Kraiem Z, Sade O, Greif J, Fireman Z
    Clin. Exp. Immunol., 2002;130(2):331-7.
    Species: Human
    Sample Type: Saliva
  61. Matrix metalloproteinase-9, but not tissue inhibitor of matrix metalloproteinase-1, increases in the sputum from allergic asthmatic patients after allergen challenge.
    Authors: Cataldo DD, Bettiol J, Noel A, Bartsch P, Foidart JM, Louis R
    Chest, 2002;122(5):1553-9.
    Species: Human
    Sample Type: Sputum
  62. Matrix metalloproteinase-9 and tissue inhibitor of matrix metalloproteinase-1: a possible role in the pathogenesis of endometriosis.
    Authors: Szamatowicz J, Laudanski P, Tomaszewska I
    Hum. Reprod., 2002;17(2):284-8.
    Species: Human
    Sample Type: Peritoneal Fluid
  63. Low-density lipoprotein receptor-related protein-1 mediates endocytic clearance of tissue inhibitor of metalloproteinases-1 and promotes its cytokine-like activities.
    Authors: Thevenard J, Verzeaux L, Devy J, Etique N, Jeanne A, Schneider C, Hachet C, Ferracci G, David M, Martiny L, Charpentier E, Khrestchatisky M, Rivera S, Dedieu S, Emonard H
    PLoS ONE, 0;9(7):e103839.
    Species: Hamster
    Sample Type: Cell Culture Supernates
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Have you used Human TIMP-1 Quantikine ELISA Kit?

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Certificate of Analysis Lookup

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