Detection of TM4SF1/L6 in A549 Human Cell Line by Flow Cytometry.
A549 human lung carcinoma cell line was stained with Mouse Anti-Human TM4SF1/L6 PE‑conjugated Monoclonal Antibody (Catalog # FAB8164P, filled histogram) or isotype control antibody (Catalog # IC002P, open histogram). View our protocol for Staining Membrane-associated Proteins.
Detection of TM4SF1/L6 in HEK293 Human Cell Line Transfected with Human TM4SF1/L6 and eGFP by Flow Cytometry.
HEK293 human embryonic kidney cell line transfected with human TM4SF1/L6 and eGFP was stained with either (A) Mouse Anti-Human TM4SF1/L6 PE‑conjugated Monoclonal Antibody (Catalog # FAB8164P) or (B) Mouse IgG1 Phycoerythrin Isotype Control (Catalog # IC002P). View our protocol for Staining Membrane-associated Proteins.
Preparation and Storage
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze.
12 months from date of receipt, 2 to 8 °C as supplied.
TM4SF1 (Transmembrane 4 L6 family Member 1; also L6 and M3s1) is a 23-28
kDa member of the L6 tetraspanin family of molecules. It is expressed
by fibroblasts, endothelial cells and a variety of tumor cells. TM4SF1
is embedded in both the plasma membrane and the membrane of late
endocytic organelles. Here, it appears to be ubiquitinated, and to
regulate endocytosis, an action that impacts effective cell migration.
TM4SF1 is reported to interact with alpha 5 and beta 1 integrins, and this may
impact cell motility. It also suppresses the expression of CD63 and
CD82, two molecules that impede cell mobility. Human TM4SF1 is a 202
amino acid (aa) 4‑transmembrane (TM) glycoprotein. It contains a short
N-terminal cytoplasmic region (aa 1-9), followed by four TM regions and
another C-terminal cytoplasmic region (aa 183-202). Human TM4SF1 shares
78% and 80% aa sequence identity with mouse and rat TM4SF1,
Transmembrane 4 L Six Family Member 1
Entrez Gene IDs:
4071 (Human); 17112 (Mouse)
L6; M3s1; M3S1Tumor-associated antigen L6; Membrane component chromosome 3 surface marker 1; membrane component, chromosome 3, surface marker 1; TAAL6; TAAL6H-L6; TM4SF1; transmembrane 4 L six family member 1; transmembrane 4 L6 family member 1; transmembrane 4 superfamily member 1
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