Human Tryptase gamma-1/TPSG1 Biotinylated Antibody
Human Tryptase gamma-1/TPSG1 Biotinylated Antibody Summary
Accession # Q9NRR2
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Tryptase gamma-1/TPSG1
As mediators of inflammatory and allergic response, mast cells are found throughout the body concentrated near blood vessels in connective tissue and the mucous membranes of the respiratory and gastrointestinal tract (3). Upon activation, human mast cells release granules that are enriched with neutral serine proteases including Tryptases, chymase and cathepsin G (4). Tryptase gamma -1, also called transmembrane Tryptase, is encoded by TPSG1, one of many serine protease genes clustered in human chromosome 16p13.3 (5). Human Tryptase gamma -1 is synthesized as a 321 amino acid preproenzyme with a C-terminal transmembrane anchor (1, 2). The rhTPSG1 was expressed as a soluble protein terminated at residue 281 and corresponded to the proenzyme. The proenzyme can be cleaved by trypsin to form the active enzyme. The serine protease activity of trypsin-activated rhTPSG1 can be inhibited by ecotin (R&D Systems, Catalog # 1328-PI). Greater than 95% protease activity is inhibited by ecotin at approximately 10:1 molar ratio.
- Wong, G.W. et al. (1999) J. Biol. Chem. 274:30784.
- Caughey, G.H. et al. (2000) J. Immunol. 164:6566.
- Harris, J.L. et al. (2001) J. Biol. Chem. 276:34941.
- Miller, H.R.P. and A.D. Pemberton (2002) Immunology 105:375.
- Wong, G.W. et al. (2002) J. Biol. Chem. 277:41906.
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