Hydroxystilbamidine bis(methanesulfonate)

Biological Activity

Hydroxystilbamidine bis(methanesulfonate) is a fluorescent cationic dye commonly used as a neuronal tracer; exhibits retrograde axonal transport. Displays different fluorescence emission wavelengths when bound to DNA compared to RNA. Visualize with an ultraviolet excitation filter. Gold color is emitted when tissue is processed with a neutral pH buffer while blue/bright white is emitted when an acidic pH buffer is used.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Motor fiber organization in the extratemporal trunk of the facial nerve in rats: A retrograde Fluoro-Gold study.
   Chen et al.
   Exp.Ther.Med., 2012;4:844
2. 2-hydroxystilbamidine isethionate: a new fluorochrome for use in general pathology. I. The selective staining of DNA, mucosubstances and elastic fibres.
   Murgatroyd et al.
   Histochemistry, 1982;74:107
3. (-)-Deprenyl increases the survival of rat retinal ganglion cells after optic nerve crush.
   Buys et al.
   Curr Eye Res., 1995;14:119
4. A beta-fiber intensity stimulation of chronically constricted median nerve induces c-fos expression in thalamic projection neurons of the cuneate nucleus in rats with behavioral signs of neuropathic pain.
   Day et al.
   Brain Res., 2001;895:194

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