Aminoglycoside antibiotic. Active against both prokaryotic and eukaryotic cells. Inhibits protein synthesis by binding to the 30S subunit and inhibiting the ribosomal translocation step of elongation.
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Hygromycin B phosphotransferase as a selectable marker for DNA transfer experiments with higher eukaryotic cells.
Blochlinger and Diggelmann
The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit.
Brodersen et al.
A ribosomal ATPase is a target for hygromycin B inhibition on Escherichia coli ribosomes.
Ganoza and Kiel
Antimicrob.Agents Chemother., 2001;45:2813