Chemical Name: O-6-Amino-6-deoxy-L-glycero-D-galacto-heptopyranosylidene-(1-2-3)-O-β-D-talopyranosyl(1-5)-2-deoxy-N3-methyl-D-streptamine
Biological ActivityAminoglycoside antibiotic. Active against both prokaryotic and eukaryotic cells. Inhibits protein synthesis by binding to the 30S subunit and inhibiting the ribosomal translocation step of elongation.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Hygromycin B phosphotransferase as a selectable marker for DNA transfer experiments with higher eukaryotic cells.
Blochlinger and Diggelmann
The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit.
Brodersen et al.
A ribosomal ATPase is a target for hygromycin B inhibition on Escherichia coli ribosomes.
Ganoza and Kiel
Antimicrob.Agents Chemother., 2001;45:2813
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Hygromycin was used as a selection marker for few eukaryotic cells which were engineered with Hygromycin resistant gene. Product works beautifully to inhibit translation and killing non resistant strains giving it desirable specificity.