Catalog Number: 4137
Chemical Name: O-6-Amino-6-deoxy-L-glycero-D-galacto-heptopyranosylidene-(1-2-3)-O-β-D-talopyranosyl(1-5)-2-deoxy-N3-methyl-D-streptamine
Biological Activity
Aminoglycoside antibiotic. Active against both prokaryotic and eukaryotic cells. Inhibits protein synthesis by binding to the 30S subunit and inhibiting the ribosomal translocation step of elongation.
Technical Data
  • M.Wt:
    527.52
  • Formula:
    C20H37N3O13
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >90%
  • Storage:
    Store at +4°C
  • CAS No:
    31282-04-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Hygromycin B phosphotransferase as a selectable marker for DNA transfer experiments with higher eukaryotic cells.
    Blochlinger and Diggelmann
    Mol.Cell.Biol., 1984;4:2929
  2. The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit.
    Brodersen et al.
    Cell, 2000;103:1143
  3. A ribosomal ATPase is a target for hygromycin B inhibition on Escherichia coli ribosomes.
    Ganoza and Kiel
    Antimicrob.Agents Chemother., 2001;45:2813

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