Chemical Name: N-5-Hexyn-1-yl-2-iodoacetamide
Biological ActivityIA-Alkyne is a broad spectrum cysteine reactive probe. Covalently binds cysteine residues in proteins. Can be utilized for covalent fragment-based ligand discovery (FBLD) and to identify Zn2+-binding cysteines. Used as a click-chemistry handle to attach a fluorophore or biotin to reactive cysteines in proteins for visualization by in-gel fluorescence or identification by mass spectrometry, respectively. Covalently binds cysteine residues in and activates TRPA1 channels.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Proteome-wide covalent ligand discovery in native biological systems.
Backus et al.
A competitive chemical-proteomic platform to identify zinc-binding cysteines.
Pace and Weerapana et al.
ACS Chem.Biol., 2014;9:258
Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines.
Macpherson et al.
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